Lys298
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Home > Sumoylation Site Page: > Lys298  -  HSF1 (human)

Site Information
SsPLVRVkEEPPsPP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 3656302

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 3 ) , mutation of modification site ( 3 ) , phospho-antibody ( 1 ) , western blotting ( 1 , 3 )
Disease tissue studied:
lung cancer ( 1 ) , non-small cell lung cancer ( 1 ) , non-small cell large cell lung carcinoma ( 1 )
Relevant cell line - cell type - tissue:
HeLa (cervical) ( 3 ) , HeLa (cervical) [HSP27 (human), transfection] ( 3 ) , NCI-H460 (pulmonary) ( 1 )

Upstream Regulation
Regulatory protein:
HSP27 (human) ( 3 )
Treatments:
siRNA ( 3 )

Downstream Regulation
Effects of modification on biological processes:
transcription, inhibited ( 3 )

References 

1

Kang GY, et al. (2015) Heat shock factor 1, an inhibitor of non-homologous end joining repair. Oncotarget 6, 29712-24
26359349   Curated Info

2

Impens F, Radoshevich L, Cossart P, Ribet D (2014) Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli. Proc Natl Acad Sci U S A 111, 12432-7
25114211   Curated Info

3

Brunet Simioni M, et al. (2009) Heat shock protein 27 is involved in SUMO-2/3 modification of heat shock factor 1 and thereby modulates the transcription factor activity. Oncogene 28, 3332-44
19597476   Curated Info

4

Hietakangas V, et al. (2006) PDSM, a motif for phosphorylation-dependent SUMO modification. Proc Natl Acad Sci U S A 103, 45-50
16371476   Curated Info

5

Hilgarth RS, Hong Y, Park-Sarge OK, Sarge KD (2003) Insights into the regulation of heat shock transcription factor 1 SUMO-1 modification. Biochem Biophys Res Commun 303, 196-200
12646186   Curated Info

6

Hong Y, et al. (2001) Regulation of heat shock transcription factor 1 by stress-induced SUMO-1 modification. J Biol Chem 276, 40263-7
11514557   Curated Info