Tyr99
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Home > Phosphorylation Site Page: > Tyr99  -  p73 (human)

Site Information
SVPTHSPyAQPSSTF   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448428

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 3 ) , immunoprecipitation ( 1 , 2 ) , mass spectrometry ( 1 ) , mutation of modification site ( 1 , 2 , 3 ) , phospho-antibody ( 2 , 3 , 4 ) , western blotting ( 1 , 2 , 3 , 4 )
Disease tissue studied:
bone cancer ( 3 ) , breast cancer ( 3 , 4 ) , colorectal cancer ( 1 ) , colorectal carcinoma ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 3 ) , COS (fibroblast) ( 3 ) , HCT116 (intestinal) [p53 (human), homozygous knockout] ( 1 ) , HeLa (cervical) ( 2 ) , MCF-7 (breast cell) ( 3 , 4 ) , MEF (fibroblast) ( 3 ) , Saos-2 (bone cell) ( 3 )

Upstream Regulation
Putative in vivo kinases:
Abl (human) ( 3 , 4 )
Kinases, in vitro:
Abl (human) ( 3 , 4 )
Treatments:
etoposide ( 1 ) , ionizing_radiation ( 3 , 4 ) , MG132 ( 1 )

Downstream Regulation
Effects of modification on p73:
activity, induced ( 3 ) , molecular association, regulation ( 1 ) , ubiquitination ( 1 )
Effects of modification on biological processes:
apoptosis, induced ( 2 , 3 ) , apoptosis, inhibited ( 1 ) , transcription, altered ( 3 ) , transcription, induced ( 1 )
Induce interaction with:
BUB3 (human) ( 2 ) , PCQAP (human) ( 1 )
Inhibit interaction with:
TIF1B (human) ( 1 )

References 

1

Satija YK, Das S (2016) Tyr99 phosphorylation determines the regulatory milieu of tumor suppressor p73. Oncogene 35, 513-27
25893286   Curated Info

2

Niikura Y, Ogi H, Kikuchi K, Kitagawa K (2010) BUB3 that dissociates from BUB1 activates caspase-independent mitotic death (CIMD). Cell Death Differ 17, 1011-24
20057499   Curated Info

3

Yuan ZM, et al. (1999) p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage. Nature 399, 814-7
10391251   Curated Info

4

Agami R, Blandino G, Oren M, Shaul Y (1999) Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis. Nature 399, 809-13
10391250   Curated Info

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