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Site Information |
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TEDTAEysPFKGGYT SwissProt Entrez-Gene |
Blast this site against: NCBI SwissProt PDB |
Site Group ID: 448413 |
In vivo Characterization | |
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Methods used to characterize site in vivo: | |
Disease tissue studied: | |
Relevant cell line - cell type - tissue: |
Upstream Regulation | |
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Kinases, in vitro: | |
Putative upstream phosphatases: | |
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Downstream Regulation | |
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Effects of modification on AR: | |
Effects of modification on biological processes: | |
Induce interaction with: | |
Inhibit interaction with: |
Disease / Diagnostics Relevance | |
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Relevant diseases: |
References | |
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Kuo YY, et al. (2019) Caffeic acid phenethyl ester suppresses androgen receptor signaling and stability via inhibition of phosphorylation on Ser81 and Ser213. Cell Commun Signal 17, 100
31429764 Curated Info |
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Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275 Curated Info |
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Lindqvist J, et al. (2015) Cyclin-dependent kinase 5 acts as a critical determinant of AKT-dependent proliferation and regulates differential gene expression by the androgen receptor in prostate cancer cells. Mol Biol Cell 26, 1971-84
25851605 Curated Info |
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Koryakina Y, Knudsen KE, Gioeli D (2015) Cell-cycle-dependent regulation of androgen receptor function. Endocr Relat Cancer 22, 249-64
25691442 Curated Info |
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Kim Y, Kim J, Jang SW, Ko J (2015) The role of sLZIP in cyclin D3-mediated negative regulation of androgen receptor transactivation and its involvement in prostate cancer. Oncogene 34, 226-36
24441043 Curated Info |
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Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451 Curated Info |
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Willder JM, et al. (2013) Androgen receptor phosphorylation at serine 515 by Cdk1 predicts biochemical relapse in prostate cancer patients. Br J Cancer 108, 139-48
23321516 Curated Info |
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McCall P, et al. (2013) Androgen receptor phosphorylation at serine 308 and serine 791 predicts enhanced survival in castrate resistant prostate cancer patients. Int J Mol Sci 14, 16656-71
23945560 Curated Info |
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Zong H, et al. (2007) Cyclin D3/CDK11p58 complex is involved in the repression of androgen receptor. Mol Cell Biol 27, 7125-42
17698582 Curated Info |
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Yang CS, et al. (2007) Ligand binding to the androgen receptor induces conformational changes that regulate phosphatase interactions. Mol Cell Biol 27, 3390-404
17325038 Curated Info |
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Yang CS, et al. (2005) Simian virus 40 small t antigen mediates conformation-dependent transfer of protein phosphatase 2A onto the androgen receptor. Mol Cell Biol 25, 1298-308
15684382 Curated Info |
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Gioeli D, et al. (2002) Androgen receptor phosphorylation. Regulation and identification of the phosphorylation sites. J Biol Chem 277, 29304-14
12015328 Curated Info |
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Zhu Z, Becklin RR, Desiderio DM, Dalton JT (2001) Identification of a novel phosphorylation site in human androgen receptor by mass spectrometry. Biochem Biophys Res Commun 284, 836-44
11396978 Curated Info |