Thr477
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Home > Phosphorylation Site Page: > Thr477  -  MLK3 (human)

Site Information
HVRRRRGtFKRSKLR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 36324901

In vivo Characterization
Methods used to characterize site in vivo:
[32P] ATP in vitro ( 2 ) , mutation of modification site ( 1 , 2 ) , western blotting ( 2 )
Disease tissue studied:
ovarian cancer ( 1 ) , pancreatic cancer ( 2 ) , pancreatic carcinoma ( 2 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , MIN6 (pancreatic) ( 2 ) , SKOV-3 (ovarian) ( 1 ) , T29 ( 1 ) , T80 ( 1 )

Upstream Regulation
Putative in vivo kinases:
Akt1 (human) ( 2 ) , LATS1 (human) ( 1 )
Kinases, in vitro:
Akt1 (human) ( 2 ) , LATS1 (human) ( 1 )
Treatments:
CEP-11004 ( 2 ) , insulin ( 2 ) , siRNA ( 1 )

Downstream Regulation
Effects of modification on MLK3:
intracellular localization ( 1 ) , molecular association, regulation ( 1 ) , protein degradation ( 2 ) , ubiquitination ( 2 )
Effects of modification on biological processes:
apoptosis, inhibited ( 2 ) , carcinogenesis, inhibited ( 1 )
Induce interaction with:
14-3-3 zeta (mouse) ( 1 )

References 

1

Kasturirangan S, Mehdi B, Chadee DN (2021) LATS1 Regulates MLK3 subcellular localization and MLK3-mediated invasion in ovarian epithelial cells. Mol Cell Biol
33875576   Curated Info

2

Humphrey RK, et al. (2014) Loss of TRB3 Alters Dynamics of MLK3-JNK Signaling and Inhibits Cytokine-activated Pancreatic Beta Cell Death. J Biol Chem 289, 29994-30004
25204656   Curated Info

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