Ser861
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.7.4
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser861  -  REST (human)

Site Information
sVsTEDLsPPsPPLP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 36320700

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry (in vitro) ( 1 ) , mutation of modification site ( 2 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Disease tissue studied:
adrenal cancer ( 2 ) , pheochromocytoma ( 2 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , HEK293T (epithelial) ( 1 , 2 ) , neuron:neurosphere-brain ( 2 ) , PC-12 (chromaffin) ( 2 )

Upstream Regulation
Regulatory protein:
HRas (human) ( 2 )
Putative in vivo kinases:
ERK1 (human) ( 2 ) , ERK2 (human) ( 2 )
Kinases, in vitro:
ERK2 (human) ( 2 )
Putative upstream phosphatases:
CTDSP1 (human) ( 1 , 2 )
Phosphatases, in vitro:
CTDSP1 (human) ( 1 )
Treatments:
EGF ( 2 ) , PD184352 ( 2 )

Downstream Regulation
Effects of modification on REST:
molecular association, regulation ( 2 ) , protein conformation ( 1 ) , protein degradation ( 1 , 2 )
Effects of modification on biological processes:
cell differentiation, inhibited ( 2 ) , transcription, induced ( 1 )
Induce interaction with:
BTRC (human) ( 2 ) , PIN1 (human) ( 2 )
Inhibit interaction with:
RCOR1 (human) ( 2 )

References 

1

Burkholder NT, et al. (2018) Phosphatase activity of Small C-terminal domain phosphatase 1 (SCP1) controls the stability of the key neuronal regulator RE1-silencing transcription factor (REST). J Biol Chem
30217818   Curated Info

2

Nesti E, et al. (2014) C-terminal domain small phosphatase 1 and MAP kinase reciprocally control REST stability and neuronal differentiation. Proc Natl Acad Sci U S A 111, E3929-36
25197063   Curated Info

3

Beli P, et al. (2012) Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response. Mol Cell 46, 212-25
22424773   Curated Info