Ser145
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Home > Phosphorylation Site Page: > Ser145  -  ERO1L (human)

Site Information
GAVDEsLsEETQkAV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 36122817

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 1 ) , immunoprecipitation ( 1 ) , mass spectrometry ( 1 , 2 , 3 , 4 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
liver cancer ( 1 ) , lung cancer ( 2 , 4 ) , non-small cell lung adenocarcinoma ( 2 , 4 )
Relevant cell line - cell type - tissue:
HeLa (cervical) ( 1 , 3 ) , HepG2 (hepatic) ( 1 ) , lung ( 4 ) , mammary gland ( 1 ) , PC9-IR (pulmonary) ( 2 )

Upstream Regulation
Putative in vivo kinases:
FAM20C (human) ( 1 )
Treatments:
brefeldin_A ( 1 ) , DTT ( 1 ) , hypoxia ( 1 ) , lactation ( 1 ) , thapsigargin ( 1 ) , tunicamycin ( 1 )

Downstream Regulation
Effects of modification on ERO1L:
enzymatic activity, induced ( 1 ) , intracellular localization ( 1 ) , protein conformation ( 1 )

References 

1

Zhang J, et al. (2018) Secretory kinase Fam20C tunes endoplasmic reticulum redox state via phosphorylation of Ero1α. EMBO J
29858230   Curated Info

2

Tsai CF, et al. (2015) Large-scale determination of absolute phosphorylation stoichiometries in human cells by motif-targeting quantitative proteomics. Nat Commun 6, 6622
25814448   Curated Info

3

Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94
25159151   Curated Info

4

Schweppe DK, Rigas JR, Gerber SA (2013) Quantitative phosphoproteomic profiling of human non-small cell lung cancer tumors. J Proteomics 91, 286-96
23911959   Curated Info