Thr91

Site Information
FGKSAKRtPESTQIG SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 36121895

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 )
Disease tissue studied:	brain cancer ( 2 ) , glioblastoma ( 2 ) , glioma ( 2 )
Relevant cell line - cell type - tissue:	HeLa (cervical) ( 1 ) , LN428_LNZ308 (glial) [EGFR (human), transfection, EGFR (wildtype)] ( 2 ) , LN428_LNZ308 (glial) [EGFR (human), transfection, EGFRvIII mutant (aka Delta EGFR, d2-7 EGFR; del. exon 2-7; in-frame loss 801 bp/267 aa in EC domain)] ( 2 ) , LN428_LNZ308 (glial) [EGFR (human), transfection, EGFRvIII-ki mutant (deletion of exons 2-7 plus kinase inactive mutation)] ( 2 )

References
1	Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94 25159151 Curated Info
2	Chumbalkar V, et al. (2011) Analysis of Phosphotyrosine Signaling in Glioblastoma Identifies STAT5 as a Novel Downstream Target of ΔEGFR. J Proteome Res 10, 1343-52 21214269 Curated Info