Thr33

Thr33

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Home > Phosphorylation Site Page: > Thr33 - BIK (human)

Site Information
TMEVLGMtDsEEDLD SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 448350

In vivo Characterization
Methods used to characterize site in vivo:	[32P] bio-synthetic labeling ( 3 ) , electrophoretic mobility shift ( 3 ) , mutation of modification site ( 2 , 3 ) , phosphoamino acid analysis ( 3 )
Relevant cell line - cell type - tissue:	BSC40 (epithelial) ( 3 ) , HEK293T (epithelial) ( 3 ) , HeLa (cervical) ( 3 ) , MCF-7 (breast cell) ( 2 ) , MDA-MB-231 (breast cell) ( 2 ) , MDA-MB-468 (breast cell) ( 2 ) , NCI-H1299 (pulmonary) ( 2 ) , PANC-1 (pancreatic) ( 2 ) , PC3 (prostate cell) ( 2 ) , SW480 (intestinal) ( 3 )

Upstream Regulation
Kinases, in vitro:	CK2A1 (human) ( 3 )

Downstream Regulation
Effects of modification on BIK:	molecular association, regulation ( 2 , 3 )
Effects of modification on biological processes:	apoptosis, induced ( 3 )
Induce interaction with:	Bcl-2 (human) ( 2 , 3 ) , Bcl-xL (human) ( 2 )

References
1	Jiao S, et al. (2014) BikDDA, a Mutant of Bik with Longer Half-Life Expression Protein, Can Be a Novel Therapeutic Gene for Triple-Negative Breast Cancer. PLoS One 9, e92172 24637719 Curated Info
2	Li YM, et al. (2003) Enhancement of Bik antitumor effect by Bik mutants. Cancer Res 63, 7630-3 14633680 Curated Info
3	Verma S, Zhao LJ, Chinnadurai G (2001) Phosphorylation of the pro-apoptotic protein BIK: mapping of phosphorylation sites and effect on apoptosis. J Biol Chem 276, 4671-6 11084041 Curated Info

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