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Site Information |
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EPDHyRYsDttDsDP SwissProt Entrez-Gene |
Blast this site against: NCBI SwissProt PDB |
Site Group ID: 448313 |
In vivo Characterization | |
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Methods used to characterize site in vivo: | |
Disease tissue studied: | |
Relevant cell line - cell type - tissue: |
Upstream Regulation | |
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Putative upstream phosphatases: | |
Phosphatases, in vitro: | |
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Downstream Regulation | |
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Effects of modification on PTEN: | |
Effects of modification on biological processes: | |
Induce interaction with: | |
Inhibit interaction with: |
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Relevant diseases: |
References | |
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Surmiak M, et al. (2023) Activity of granulomatosis with polyangiitis and its correlation with mTOR phosphoproteomics in neutrophils. Front Immunol 14, 1227369
37720230 Curated Info |
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Misra S, et al. (2022) Both phosphorylation and phosphatase activity of PTEN are required to prevent replication fork progression during stress by inducing heterochromatin. Mutat Res 825, 111800
36155262 Curated Info |
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Viswanathan TM, et al. (2022) Guanidine-Curcumin Complex-Loaded Amine-Functionalised Hollow Mesoporous Silica Nanoparticles for Breast Cancer Therapy. Cancers (Basel) 14
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Kilbas PO, et al. (2022) CRISPR/Cas9-mediated Bag-1 knockout increased mesenchymal characteristics of MCF-7 cells via Akt hyperactivation-mediated actin cytoskeleton remodeling. PLoS One 17, e0261062
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Stuani L, et al. (2021) Mitochondrial metabolism supports resistance to IDH mutant inhibitors in acute myeloid leukemia. J Exp Med 218
33760042 Curated Info |
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Perera Y, et al. (2020) Clinical-Grade Peptide-Based Inhibition of CK2 Blocks Viability and Proliferation of T-ALL Cells and Counteracts IL-7 Stimulation and Stromal Support. Cancers (Basel)
32471246 Curated Info |
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Yang JM, et al. (2017) Characterization of PTEN mutations in brain cancer reveals that pten mono-ubiquitination promotes protein stability and nuclear localization. Oncogene 36, 3673-3685
28263967 Curated Info |
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Guo ST, et al. (2016) INPP4B is an oncogenic regulator in human colon cancer. Oncogene 35, 3049-61
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Lechman ER, et al. (2016) miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells. Cancer Cell 29, 214-28
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Kim SJ, et al. (2016) Activation of nuclear PTEN by inhibition of Notch signaling induces G2/M cell cycle arrest in gastric cancer. Oncogene 35, 251-60
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Choi BH, Pagano M, Dai W (2014) Plk1 Protein Phosphorylates Phosphatase and Tensin Homolog (PTEN) and Regulates Its Mitotic Activity during the Cell Cycle. J Biol Chem 289, 14066-74
24706748 Curated Info |
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Papa A, et al. (2014) Cancer-Associated PTEN Mutants Act in a Dominant-Negative Manner to Suppress PTEN Protein Function. Cell 157, 595-610
24766807 Curated Info |
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Choi BH, Chen Y, Dai W (2013) Chromatin PTEN is involved in DNA damage response partly through regulating Rad52 sumoylation. Cell Cycle 12, 3442-7
24047694 Curated Info |
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Zhang XC, et al. (2012) Functional analysis of the protein phosphatase activity of PTEN. Biochem J 444, 457-64
22413754 Curated Info |
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Roy D, Dittmer DP (2011) Phosphatase and tensin homolog on chromosome 10 is phosphorylated in primary effusion lymphoma and Kaposi's sarcoma. Am J Pathol 179, 2108-19
21819957 Curated Info |
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Zhang P, et al. (2011) Cross-talk between phospho-STAT3 and PLCĪ³1 plays a critical role in colorectal tumorigenesis. Mol Cancer Res 9, 1418-28
21840932 Curated Info |
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Murata H, et al. (2011) A new cytosolic pathway from a Parkinson disease-associated kinase, BRPK/PINK1: activation of AKT via mTORC2. J Biol Chem 286, 7182-9
21177249 Curated Info |
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Siddiqui-Jain A, et al. (2010) CX-4945, an orally bioavailable selective inhibitor of protein kinase CK2, inhibits prosurvival and angiogenic signaling and exhibits antitumor efficacy. Cancer Res 70, 10288-98
21159648 Curated Info |
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Eto I (2010) Upstream molecular signaling pathways of p27(Kip1) expression: Effects of 4-hydroxytamoxifen, dexamethasone, and retinoic acids. Cancer Cell Int 10, 3
20170512 Curated Info |
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Koomoa DL, et al. (2008) Ornithine decarboxylase inhibition by alpha-difluoromethylornithine activates opposing signaling pathways via phosphorylation of both Akt/protein kinase B and p27Kip1 in neuroblastoma. Cancer Res 68, 9825-31
19047162 Curated Info |
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Song P, et al. (2008) Protein kinase Czeta-dependent LKB1 serine 428 phosphorylation increases LKB1 nucleus export and apoptosis in endothelial cells. J Biol Chem 283, 12446-55
18321849 Curated Info |
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Selvendiran K, et al. (2007) EF24 induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by increasing PTEN expression. J Biol Chem 282, 28609-18
17684018 Curated Info |
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Odriozola L, Singh G, Hoang T, Chan AM (2007) Regulation of PTEN activity by its carboxyl-terminal autoinhibitory domain. J Biol Chem 282, 23306-15
17565999 Curated Info |
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Leslie NR, Yang X, Downes CP, Weijer CJ (2007) PtdIns(3,4,5)P(3)-dependent and -independent roles for PTEN in the control of cell migration. Curr Biol 17, 115-25
17240336 Curated Info |
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Rafiq K, et al. (2006) Role of protein-tyrosine phosphatase SHP2 in focal adhesion kinase down-regulation during neutrophil cathepsin G-induced cardiomyocytes anoikis. J Biol Chem 281, 19781-92
16690621 Curated Info |
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Al-Khouri AM, et al. (2005) Cooperative phosphorylation of the tumor suppressor phosphatase and tensin homologue (PTEN) by casein kinases and glycogen synthase kinase 3beta. J Biol Chem 280, 35195-202
16107342 Curated Info |
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Sabnis GJ, Jelovac D, Long B, Brodie A (2005) The role of growth factor receptor pathways in human breast cancer cells adapted to long-term estrogen deprivation. Cancer Res 65, 3903-10
15867390 Curated Info |
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Lu Y, et al. (2003) Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol 3-kinase/AKT cascades. J Biol Chem 278, 40057-66
12869565 Curated Info |
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Birle D, et al. (2002) Negative feedback regulation of the tumor suppressor PTEN by phosphoinositide-induced serine phosphorylation. J Immunol 169, 286-91
12077256 Curated Info |
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Torres J, Pulido R (2001) The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation. J Biol Chem 276, 993-8
11035045 Curated Info |
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Vazquez F, Ramaswamy S, Nakamura N, Sellers WR (2000) Phosphorylation of the PTEN tail regulates protein stability and function. Mol Cell Biol 20, 5010-8
10866658 Curated Info |