Tyr220
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Home > Phosphorylation Site Page: > Tyr220  -  p53 (human)

Site Information
rHsVVVPyEPPEVGS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 34824801

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
Src (human) ( 1 )
Kinases, in vitro:
Src (human) ( 1 )

Downstream Regulation
Effects of modification on p53:
activity, inhibited ( 1 ) , molecular association, regulation ( 1 ) , protein degradation ( 1 )
Effects of modification on biological processes:
carcinogenesis, induced ( 1 ) , DNA repair, inhibited ( 1 )
Induce interaction with:
HERC5 (human) ( 1 )

References 

1

Huang YF, Bulavin DV (2014) Oncogene-mediated regulation of p53 ISGylation and functions. Oncotarget 5, 5808-18
25071020   Curated Info