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Site Information |
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EtPPRPRtPGRPLss SwissProt Entrez-Gene |
Blast this site against: NCBI SwissProt PDB |
Site Group ID: 448287 |
In vivo Characterization | |
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Methods used to characterize site in vivo: | |
Disease tissue studied: | |
Relevant cell line - cell type - tissue: |
Upstream Regulation | |
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Kinases, in vitro: | |
Putative upstream phosphatases: | |
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Downstream Regulation | |
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Effects of modification on MEK1: | |
Effects of modification on biological processes: | |
Induce interaction with: | |
Inhibit interaction with: |
References | |
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Cho E, et al. (2021) PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK. Cell Rep 34, 108928
33789117 Curated Info |
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Kinoshita E, et al. (2016) A Phos-tag SDS-PAGE method that effectively uses phosphoproteomic data for profiling the phosphorylation dynamics of MEK1. Proteomics 16, 1825-36
27169363 Curated Info |
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Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275 Curated Info |
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Carrier M, et al. (2016) Phosphoproteome and Transcriptome of RA-Responsive and RA-Resistant Breast Cancer Cell Lines. PLoS One 11, e0157290
27362937 Curated Info |
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Tassin TC, et al. (2015) Regulation of ERK Kinase by MEK1 Kinase Inhibition in the Brain. J Biol Chem 290, 16319-29
25971971 Curated Info |
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Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94
25159151 Curated Info |
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Bian Y, et al. (2014) An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics 96, 253-62
24275569 Curated Info |
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Zhong D, et al. (2009) The Glycolytic Inhibitor 2-Deoxyglucose Activates Multiple Prosurvival Pathways through IGF1R. J Biol Chem 284, 23225-33
19574224 Curated Info |
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Eblen ST, et al. (2004) Mitogen-activated protein kinase feedback phosphorylation regulates MEK1 complex formation and activation during cellular adhesion. Mol Cell Biol 24, 2308-17
14993270 Curated Info |
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Harding A, et al. (2003) Mechanism of mitosis-specific activation of MEK1. J Biol Chem 278, 16747-54
12609978 Curated Info |
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Xu B, Wilsbacher JL, Collisson T, Cobb MH (1999) The N-terminal ERK-binding site of MEK1 is required for efficient feedback phosphorylation by ERK2 in vitro and ERK activation in vivo. J Biol Chem 274, 34029-35
10567369 Curated Info |
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Frost JA, et al. (1997) Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins. EMBO J 16, 6426-38
9351825 Curated Info |
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Rossomando AJ, Dent P, Sturgill TW, Marshak DR (1994) Mitogen-activated protein kinase kinase 1 (MKK1) is negatively regulated by threonine phosphorylation. Mol Cell Biol 14, 1594-602
8114697 Curated Info |