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Site Information |
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RtPGRPLssyGMDSR SwissProt Entrez-Gene |
Blast this site against: NCBI SwissProt PDB |
Site Group ID: 448284 |
In vivo Characterization | |
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Methods used to characterize site in vivo: | |
Disease tissue studied: | |
Relevant cell line - cell type - tissue: |
Upstream Regulation | |
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Downstream Regulation | |
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Effects of modification on MEK1: | |
Effects of modification on biological processes: | |
Induce interaction with: |
References | |
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Chan CH, et al. (2023) PAK and PI3K pathway activation confers resistance to KRAS inhibitor sotorasib. Br J Cancer 128, 148-159
36319849 Curated Info |
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Yin Y, et al. (2022) Functional testing to characterize and stratify PI3K inhibitor responses in chronic lymphocytic leukemia. Clin Cancer Res 28
35998013 Curated Info |
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Cho E, et al. (2021) PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK. Cell Rep 34, 108928
33789117 Curated Info |
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Feddersen CR, et al. (2019) Src-dependent DBL family members drive resistance to vemurafenib in human melanoma. Cancer Res
31416844 Curated Info |
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Procaccia S, et al. (2017) Direct binding of MEK1 and MEK2 to AKT induces Foxo1 phosphorylation, cellular migration and metastasis. Sci Rep 7, 43078
28225038 Curated Info |
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Kinoshita E, et al. (2016) A Phos-tag SDS-PAGE method that effectively uses phosphoproteomic data for profiling the phosphorylation dynamics of MEK1. Proteomics 16, 1825-36
27169363 Curated Info |
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Carrier M, et al. (2016) Phosphoproteome and Transcriptome of RA-Responsive and RA-Resistant Breast Cancer Cell Lines. PLoS One 11, e0157290
27362937 Curated Info |
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Hammer A, Diakonova M (2016) Prolactin-induced PAK1 tyrosyl phosphorylation promotes FAK dephosphorylation, breast cancer cell motility, invasion and metastasis. BMC Cell Biol 17, 31
27542844 Curated Info |
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Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94
25159151 Curated Info |
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Yi C, et al. (2011) A tight junction-associated Merlin-angiomotin complex mediates Merlin's regulation of mitogenic signaling and tumor suppressive functions. Cancer Cell 19, 527-40
21481793 Curated Info |
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Murphy EA, et al. (2010) Disruption of angiogenesis and tumor growth with an orally active drug that stabilizes the inactive state of PDGFRbeta/B-RAF. Proc Natl Acad Sci U S A 107, 4299-304
20154271 Curated Info |
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Zang M, et al. (2008) Characterization of Ser338 phosphorylation for Raf-1 activation. J Biol Chem 283, 31429-37
18775988 Curated Info |
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Moniz S, Matos P, Jordan P (2008) WNK2 modulates MEK1 activity through the Rho GTPase pathway. Cell Signal 20, 1762-8
18593598 Curated Info |
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Moniz S, et al. (2007) Protein kinase WNK2 inhibits cell proliferation by negatively modulating the activation of MEK1/ERK1/2. Oncogene 26, 6071-81
17667937 Curated Info |
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Sastry KS, Karpova Y, Kulik G (2006) Epidermal growth factor protects prostate cancer cells from apoptosis by inducing BAD phosphorylation via redundant signaling pathways. J Biol Chem 281, 27367-77
16847055 Curated Info |
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Beeser A, Jaffer ZM, Hofmann C, Chernoff J (2005) Role of group A p21-activated kinases in activation of extracellular-regulated kinase by growth factors. J Biol Chem 280, 36609-15
16129686 Curated Info |
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Eblen ST, et al. (2004) Mitogen-activated protein kinase feedback phosphorylation regulates MEK1 complex formation and activation during cellular adhesion. Mol Cell Biol 24, 2308-17
14993270 Curated Info |
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Coles LC, Shaw PE (2002) PAK1 primes MEK1 for phosphorylation by Raf-1 kinase during cross-cascade activation of the ERK pathway. Oncogene 21, 2236-44
11948406 Curated Info |
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Frost JA, et al. (1997) Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins. EMBO J 16, 6426-38
9351825 Curated Info |
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Wang J, Vantus T, Merlevede W, Vandenheede JR (1997) Identification and characterization of an auto-activating MEK kinase from bovine brain: phosphorylation of serine-298 in the proline-rich domain of the mammalian MEKs. Int J Biochem Cell Biol 29, 1071-83
9416003 Curated Info |