Thr211
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Home > Phosphorylation Site Page: > Thr211  -  MKK6 (human)

Site Information
LVDsVAKtIDAGCKP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448195

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 2 , 3 , 4 ) , mutation of modification site ( 6 )
Disease tissue studied:
HER2 positive breast cancer ( 1 ) , luminal A breast cancer ( 1 ) , luminal B breast cancer ( 1 ) , breast cancer, triple negative ( 1 ) , lung cancer ( 4 ) , non-small cell lung cancer ( 4 )
Relevant cell line - cell type - tissue:
breast ( 1 ) , CHO (fibroblast) [EphB1 (human), transfection] ( 6 ) , COS (fibroblast) ( 6 ) , Jurkat (T lymphocyte) ( 3 ) , lung ( 4 )

Upstream Regulation
Putative in vivo kinases:
TAK1 (human) ( 5 )

Downstream Regulation
Effects of modification on MKK6:
enzymatic activity, induced ( 6 )
Effects of modification on biological processes:
transcription, induced ( 6 )

References 

1

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

2

Stokes MP, et al. (2012) PTMScan Direct: Identification and Quantification of Peptides from Critical Signaling Proteins by Immunoaffinity Enrichment Coupled with LC-MS/MS. Mol Cell Proteomics 11, 187-201
22322096   Curated Info

3

Mulhern D (2012) CST Curation Set: 13108; Year: 2012; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY])
Curated Info

4

Rikova K (2010) CST Curation Set: 9756; Year: 2010; Biosample/Treatment: tissue, lung/untreated; Disease: non-small cell lung cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY])
Curated Info

5

Wang C, et al. (2001) TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature 412, 346-51
11460167   Curated Info

6

Raingeaud J, et al. (1996) MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway. Mol Cell Biol 16, 1247-55
8622669   Curated Info