Lys492
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Home > Sumoylation Site Page: > Lys492  -  PLK1 (human)

Site Information
YMSEHLLkAGANItP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 334535808

In vivo Characterization
Methods used to characterize site in vivo:
flow cytometry ( 1 ) , immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
bone cancer ( 1 )
Relevant cell line - cell type - tissue:

Downstream Regulation
Effects of modification on PLK1:
intracellular localization ( 1 ) , molecular association, regulation ( 1 ) , protein stabilization ( 1 )
Effects of modification on biological processes:
cell cycle regulation ( 1 )
Inhibit interaction with:
CDH1 (human) ( 1 )

References 

1

Wen D, Wu J, Wang L, Fu Z (2017) SUMOylation Promotes Nuclear Import and Stabilization of Polo-like Kinase 1 to Support Its Mitotic Function. Cell Rep 21, 2147-2159
29166606   Curated Info