Tyr568
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Home > Phosphorylation Site Page: > Tyr568  -  NRF2 (mouse)

Site Information
RDEDGKPySPSEYSL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 460703

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 , 3 ) , mutation of modification site ( 1 , 3 ) , phospho-antibody ( 1 , 2 , 3 ) , western blotting ( 1 , 2 )
Disease tissue studied:
breast cancer ( 1 ) , liver cancer ( 1 , 2 )
Relevant cell line - cell type - tissue:
BT-549 (breast cell) ( 1 ) , Hepa-1 (hepatic) ( 1 , 3 ) , HepG2 (hepatic) ( 2 ) , MCF-7 (breast cell) ( 1 )

Upstream Regulation
Putative in vivo kinases:
Fyn (mouse) ( 3 )
Treatments:
H2O2 ( 2 , 3 ) , lithium ( 2 ) , PP2 ( 3 ) , tBHQ ( 1 )

Downstream Regulation
Effects of modification on NRF2:
intracellular localization ( 2 , 3 ) , molecular association, regulation ( 3 ) , protein degradation ( 2 , 3 ) , ubiquitination ( 2 )
Induce interaction with:
Exportin-1 (mouse) ( 3 )

References 

1

Niture SK, Jain AK, Jaiswal AK (2009) Antioxidant-induced modification of INrf2 cysteine 151 and PKC-delta-mediated phosphorylation of Nrf2 serine 40 are both required for stabilization and nuclear translocation of Nrf2 and increased drug resistance. J Cell Sci 122, 4452-64
19920073   Curated Info

2

Jain AK, Jaiswal AK (2007) GSK-3beta acts upstream of Fyn kinase in regulation of nuclear export and degradation of NF-E2 related factor 2. J Biol Chem 282, 16502-10
17403689   Curated Info

3

Jain AK, Jaiswal AK (2006) Phosphorylation of tyrosine 568 controls nuclear export of Nrf2. J Biol Chem 281, 12132-42
16513647   Curated Info

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