Thr377
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Home > Phosphorylation Site Page: > Thr377  -  p53 (human)

Site Information
kskkGQstsRHkkLM   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 3309800

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mutation of modification site ( 1 , 4 ) , phospho-antibody ( 2 ) , western blotting ( 2 , 4 )
Disease tissue studied:
neuroblastoma ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
LRRK2 (human) ( 2 )
Kinases, in vitro:
LRRK2 (human) ( 2 ) , PKCA (human) ( 4 )

Downstream Regulation
Effects of modification on p53:
intracellular localization ( 2 )
Effects of modification on biological processes:
apoptosis, induced ( 1 , 2 ) , transcription, induced ( 1 , 2 ) , translation, induced ( 1 )

References 

1

Ho DH, Seol W, Eun JH, Son IH (2017) Phosphorylation of p53 by LRRK2 induces microglial tumor necrosis factor α-mediated neurotoxicity. Biochem Biophys Res Commun 482, 1088-1094
27914807   Curated Info

2

Ho DH, et al. (2015) Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21(WAF1/CIP1) expression. Mol Brain 8, 54
26384650   Curated Info

3

van Dieck J, et al. (2009) Posttranslational modifications affect the interaction of S100 proteins with tumor suppressor p53. J Mol Biol 394, 922-30
19819244   Curated Info

4

Youmell M, Park SJ, Basu S, Price BD (1998) Regulation of the p53 protein by protein kinase C alpha and protein kinase C zeta. Biochem Biophys Res Commun 245, 514-8
9571186   Curated Info

5

Lu H, Fisher RP, Bailey P, Levine AJ (1997) The CDK7-cycH-p36 complex of transcription factor IIH phosphorylates p53, enhancing its sequence-specific DNA binding activity in vitro. Mol Cell Biol 17, 5923-34
9315650   Curated Info