Lys331
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Home > Acetylation Site Page: > Lys331  -  p73 (human)

Site Information
AASkRAFkQsPPAVP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 460607

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , modification-specific antibody ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
bone cancer ( 1 ) , colorectal cancer ( 1 ) , colorectal carcinoma ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
Abl (human) ( 1 ) , CBP (human) ( 1 ) , PCAF (human) ( 1 )
Treatments:
adriamycin ( 1 ) , LysCoA ( 1 )

Downstream Regulation
Effects of modification on p73:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
apoptosis, induced ( 1 ) , cell growth, inhibited ( 1 ) , transcription, induced ( 1 )
Induce interaction with:
DNA ( 1 )

References 

1

Costanzo A, et al. (2002) DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes. Mol Cell 9, 175-86
11804596   Curated Info