Ser4391

Site Information
AGGFRsRsssVGsss SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 459949

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 3 , 4 , 5 , 6 , 7 )
Disease tissue studied:	neuroblastoma ( 3 ) , melanoma skin cancer ( 7 )
Relevant cell line - cell type - tissue:	'fat, brown' ( 4 ) , brain ( 4 ) , C2C12 (myoblast) ( 1 ) , fibroblast-lung ( 6 ) , heart ( 4 ) , kidney ( 4 ) , liver ( 4 ) , lung ( 4 ) , MEF (fibroblast) [p53 (mouse), homozygous knockout] ( 2 ) , mpkCCD (renal) ( 5 ) , N1E-115 (neuron) ( 3 ) , pancreas ( 4 ) , skin [mGluR1 (mouse), transgenic, TG mutant mice] ( 7 ) , spleen ( 4 ) , testis ( 4 )

Upstream Regulation
Treatments:	LPA ( 3 ) , SB202190 ( 1 )

References
1	Knight JD, et al. (2012) A novel whole-cell lysate kinase assay identifies substrates of the p38 MAPK in differentiating myoblasts. Skelet Muscle 2, 5 22394512 Curated Info
2	Hsu PP, et al. (2011) The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 332, 1317-22 21659604 Curated Info
3	Wang Y, et al. (2011) Spatial phosphoprotein profiling reveals a compartmentalized extracellular signal-regulated kinase switch governing neurite growth and retraction. J Biol Chem 286, 18190-201 21454597 Curated Info
4	Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89 21183079 Curated Info
5	Rinschen MM, et al. (2010) Quantitative phosphoproteomic analysis reveals vasopressin V2-receptor-dependent signaling pathways in renal collecting duct cells. Proc Natl Acad Sci U S A 107, 3882-7 20139300 Curated Info
6	Guo A (2009) CST Curation Set: 6842; Year: 2009; Biosample/Treatment: cell line, mouse lung fibroblasts/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST] Antibodies Used to Purify Peptides prior to LCMS: Phospho-Akt Substrate (RXRXXS/T) (23C8D2) Rabbit mAb Cat#: 10001, PTMScan(R) Phospho-Akt Substrate Motif (RXRXXS/T) Immunoaffinity Beads Cat#: 1979 Curated Info
7	Zanivan S, et al. (2008) Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry. J Proteome Res 7, 5314-26 19367708 Curated Info