Ser137
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Home > Phosphorylation Site Page: > Ser137  -  PLK1 (human)

Site Information
LELCRRRsLLELHkR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448138

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 5 ) , mass spectrometry ( 2 ) , mass spectrometry (in vitro) ( 2 ) , mutation of modification site ( 3 , 4 , 5 , 6 ) , phospho-antibody ( 3 , 4 , 5 ) , western blotting ( 3 , 4 , 5 )
Disease tissue studied:
bone cancer ( 4 ) , colorectal cancer ( 3 ) , colorectal carcinoma ( 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
Cot (human) ( 2 ) , PLK2 (human) ( 3 )
Kinases, in vitro:
Cot (human) ( 2 ) , PLK2 (human) ( 3 )
Treatments:
adriamycin ( 5 ) , MG132 ( 4 ) , nocodazole ( 5 )

Downstream Regulation
Effects of modification on PLK1:
enzymatic activity, induced ( 4 , 6 )
Effects of modification on biological processes:
apoptosis, inhibited ( 3 ) , cell cycle regulation ( 4 , 6 ) , cell growth, induced ( 3 )

References 

1

Shiromizu T, et al. (2013) Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res 12, 2414-21
23312004   Curated Info

2

Wu B, Jiang P, Mu Y, Wilmouth RC (2009) Cancer Osaka thyroid (Cot) phosphorylates Polo-like kinase (PLK1) at Ser137 but not at Thr210. Biol Chem 390, 1271-7
19804365   Curated Info

3

Matsumoto T, et al. (2009) Polo-like kinases mediate cell survival in mitochondrial dysfunction. Proc Natl Acad Sci U S A 106, 14542-6
19706541   Curated Info

4

van de Weerdt BC, et al. (2005) Uncoupling anaphase-promoting complex/cyclosome activity from spindle assembly checkpoint control by deregulating polo-like kinase 1. Mol Cell Biol 25, 2031-44
15713655   Curated Info

5

Tsvetkov L, Stern DF (2005) Phosphorylation of Plk1 at S137 and T210 is inhibited in response to DNA damage. Cell Cycle 4, 166-71
15611664   Curated Info

6

Jang YJ, Ma S, Terada Y, Erikson RL (2002) Phosphorylation of threonine 210 and the role of serine 137 in the regulation of mammalian polo-like kinase. J Biol Chem 277, 44115-20
12207013   Curated Info