Tyr66
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Home > Phosphorylation Site Page: > Tyr66  -  RRas (human)

Site Information
DPTIEDSyTKICSVD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448122

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 3 ) , immunoprecipitation ( 3 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 2 , 3 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:
COS (fibroblast) ( 1 ) , HEK293T (epithelial) ( 2 , 3 ) , MDCK (epithelial) ( 2 ) , neuron-'brain, hippocampus' ( 1 ) , retina ( 1 )

Upstream Regulation
Putative in vivo kinases:
Src (human) ( 2 )
Kinases, in vitro:
EphB2 (human) ( 3 )

Downstream Regulation
Effects of modification on RRas:
molecular association, regulation ( 3 )
Effects of modification on biological processes:
cell adhesion, altered ( 2 , 3 ) , cell motility, altered ( 1 ) , cytoskeletal reorganization ( 1 )

References 

1

Dail M, Richter M, Godement P, Pasquale EB (2006) Eph receptors inactivate R-Ras through different mechanisms to achieve cell repulsion. J Cell Sci 119, 1244-54
16522685   Curated Info

2

Zou JX, Liu Y, Pasquale EB, Ruoslahti E (2002) Activated SRC oncogene phosphorylates R-ras and suppresses integrin activity. J Biol Chem 277, 1824-7
11682467   Curated Info

3

Zou JX, et al. (1999) An Eph receptor regulates integrin activity through R-Ras. Proc Natl Acad Sci U S A 96, 13813-8
10570155   Curated Info