Ser470

Site Information
ADGKLsGsKAktWMV SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 3214362

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 3 , 4 , 5 , 6 , 7 )
Disease tissue studied:	breast cancer ( 2 ) , lung cancer ( 2 ) , non-small cell lung cancer ( 2 )
Relevant cell line - cell type - tissue:	BT-549 (breast cell) ( 2 ) , Calu 6 (pulmonary) ( 2 ) , endothelial-aorta ( 3 ) , H2009 (pulmonary) ( 2 ) , H2077 (pulmonary) ( 2 ) , H2887 (pulmonary) ( 2 ) , H322M (pulmonary) ( 2 ) , HCC1359 (pulmonary) ( 2 ) , HCC1937 (breast cell) ( 2 ) , HCC2279 (pulmonary) ( 2 ) , HCC366 (pulmonary) ( 2 ) , HCC4006 (pulmonary) ( 2 ) , HCC78 (pulmonary) ( 2 ) , HCC827 (pulmonary) ( 2 ) , HeLa (cervical) ( 1 , 4 , 5 , 6 ) , HOP62 (pulmonary) ( 2 ) , Jurkat (T lymphocyte) ( 7 ) , K562 (erythroid) ( 1 ) , LCLC-103H (pulmonary) ( 2 ) , LOU-NH91 (squamous) ( 2 ) , MCF-7 (breast cell) ( 2 ) , MDA-MB-231 (breast cell) ( 2 ) , NCI-H1395 (pulmonary) ( 2 ) , NCI-H157 (pulmonary) ( 2 ) , NCI-H1648 (pulmonary) ( 2 ) , NCI-H1666 (pulmonary) ( 2 ) , NCI-H2030 (pulmonary) ( 2 ) , NCI-H2172 (pulmonary) ( 2 ) , NCI-H322 (pulmonary) ( 2 ) , NCI-H460 (pulmonary) ( 2 ) , NCI-H520 (squamous) ( 2 ) , PC9 (pulmonary) ( 2 )

References
1	Zhou H, et al. (2013) Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res 12, 260-71 23186163 Curated Info
2	Klammer M, et al. (2012) Phosphosignature predicts dasatinib response in non-small cell lung cancer. Mol Cell Proteomics 11, 651-68 22617229 Curated Info
3	Verano-Braga T, et al. (2012) Time-resolved quantitative phosphoproteomics: new insights into Angiotensin-(1-7) signaling networks in human endothelial cells. J Proteome Res 11, 3370-81 22497526 Curated Info
4	Chen RQ, et al. (2009) CDC25B mediates rapamycin-induced oncogenic responses in cancer cells. Cancer Res 69, 2663-8 19276368 Curated Info
5	Dephoure N, et al. (2008) A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A 105, 10762-7 18669648 Curated Info
6	Ruse CI, et al. (2008) Motif-specific sampling of phosphoproteomes. J Proteome Res 7, 2140-50 18452278 Curated Info
7	Possemato A (2007) CST Curation Set: 3170; Year: 2007; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info