Ser46

Site Information
LsPGsLRsAAHsPLD SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 3208734

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 3 , 4 , 5 , 6 )
Disease tissue studied:	cervical cancer ( 4 ) , cervical adenocarcinoma ( 4 ) , lung cancer ( 2 ) , non-small cell lung cancer ( 2 )
Relevant cell line - cell type - tissue:	HeLa (cervical) ( 1 , 3 , 5 , 6 ) , HeLa S3 (cervical) ( 4 ) , LOU-NH91 (squamous) ( 2 ) , NCI-H1395 (pulmonary) ( 2 ) , NCI-H2030 (pulmonary) ( 2 ) , NCI-H460 (pulmonary) ( 2 ) , NCI-H520 (squamous) ( 2 ) , PC9 (pulmonary) ( 2 )

Upstream Regulation
Treatments:	nocodazole ( 4 )

References
1	Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94 25159151 Curated Info
2	Klammer M, et al. (2012) Phosphosignature predicts dasatinib response in non-small cell lung cancer. Mol Cell Proteomics 11, 651-68 22617229 Curated Info
3	Kettenbach AN, et al. (2011) Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells. Sci Signal 4, rs5 21712546 Curated Info
4	Olsen JV, et al. (2010) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal 3, ra3 20068231 Curated Info
5	Pan C, Olsen JV, Daub H, Mann M (2009) Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics. Mol Cell Proteomics 8, 2796-808 19651622 Curated Info
6	Dephoure N, et al. (2008) A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A 105, 10762-7 18669648 Curated Info