Ser684

Site Information
KGQHtLKsPPsQSVQ SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 3207072

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 3 , 5 , 6 , 7 , 8 )
Disease tissue studied:	cervical cancer ( 7 ) , cervical adenocarcinoma ( 7 ) , lung cancer ( 3 ) , non-small cell lung cancer ( 3 )
Relevant cell line - cell type - tissue:	HCC2279 (pulmonary) ( 3 ) , HeLa (cervical) ( 1 , 2 , 6 ) , HeLa S3 (cervical) [PLK1 (human), knockdown, Tet-inducible PLK1 siRNA] ( 5 ) , HeLa S3 (cervical) ( 5 , 7 , 8 ) , NCI-H2172 (pulmonary) ( 3 )

Downstream Regulation
Effects of modification on KIF18A:	enzymatic activity, inhibited ( 1 ) , molecular association, regulation ( 1 )
Effects of modification on biological processes:	cell cycle regulation ( 1 )
Induce interaction with:	PPP2R3A (human) ( 1 ) , PPP2R3B (human) ( 1 )
Inhibit interaction with:	PPP2R2C (human) ( 1 ) , PPP2R5C (human) ( 1 )

References
1	Nasa I, et al. (2020) Quantitative kinase and phosphatase profiling reveal that CDK1 phosphorylates PP2Ac to promote mitotic entry. Sci Signal 13 32900880 Curated Info
2	Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94 25159151 Curated Info
3	Klammer M, et al. (2012) Phosphosignature predicts dasatinib response in non-small cell lung cancer. Mol Cell Proteomics 11, 651-68 22617229 Curated Info
4	Beli P, et al. (2012) Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response. Mol Cell 46, 212-25 22424773 Curated Info
5	Santamaria A, et al. (2011) The Plk1-dependent phosphoproteome of the early mitotic spindle. Mol Cell Proteomics 10, M110.004457 20860994 Curated Info
6	Kettenbach AN, et al. (2011) Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells. Sci Signal 4, rs5 21712546 Curated Info
7	Olsen JV, et al. (2010) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal 3, ra3 20068231 Curated Info
8	Malik R, et al. (2009) Quantitative analysis of the human spindle phosphoproteome at distinct mitotic stages. J Proteome Res 8, 4553-63 19691289 Curated Info