Ser222
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Home > Phosphorylation Site Page: > Ser222  -  NFkB-p100 (human)

Site Information
QPIHDSKsPGASNLk   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 3193889

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 2 , 3 , 7 ) , mutation of modification site ( 8 ) , phospho-antibody ( 8 ) , western blotting ( 8 )
Disease tissue studied:
bone cancer ( 8 ) , HER2 positive breast cancer ( 2 ) , luminal A breast cancer ( 2 ) , luminal B breast cancer ( 2 ) , breast cancer, surrounding tissue ( 2 ) , breast cancer, triple negative ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
Bcl-3 (human) ( 8 )
Putative in vivo kinases:
GSK3B (human) ( 8 )
Kinases, in vitro:
GSK3B (human) ( 8 )
Treatments:
CT-99021 ( 8 ) , UV ( 8 )

Downstream Regulation
Effects of modification on NFkB-p100:
molecular association, regulation ( 8 )
Effects of modification on biological processes:
transcription, altered ( 8 )
Induce interaction with:
REL (human) ( 8 )
Inhibit interaction with:
Bcl-3 (human) ( 8 ) , NFkB-p100 (human) ( 8 )

References 

1

Bouhaddou M, et al. (2020) The Global Phosphorylation Landscape of SARS-CoV-2 Infection. Cell 182
32645325   Curated Info

2

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

3

Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94
25159151   Curated Info

4

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

5

Shiromizu T, et al. (2013) Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res 12, 2414-21
23312004   Curated Info

6

Beli P, et al. (2012) Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response. Mol Cell 46, 212-25
22424773   Curated Info

7

Kettenbach AN, et al. (2011) Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells. Sci Signal 4, rs5
21712546   Curated Info

8

Barré B, Perkins ND (2010) The Skp2 promoter integrates signaling through the NF-kappaB, p53, and Akt/GSK3beta pathways to regulate autophagy and apoptosis. Mol Cell 38, 524-38
20513428   Curated Info