Thr1381
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Home > Phosphorylation Site Page: > Thr1381  -  MEKK1 (mouse)

Site Information
ARLASKGtGAGEFQG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448078

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 2 , 3 ) , mutation of modification site ( 2 , 3 ) , phospho-antibody ( 1 ) , phosphoamino acid analysis ( 3 ) , phosphopeptide mapping ( 2 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , COS (fibroblast) [MEKK1 (mouse)] ( 2 ) , CV1 (fibroblast) ( 3 ) , ES (stem) ( 1 ) , T.ni [MEKK1 (mouse)] ( 2 )

Upstream Regulation
Putative in vivo kinases:
MEKK1 (mouse) ( 3 )
Kinases, in vitro:
MEKK1 (mouse) ( 2 , 3 )
Treatments:
phorbol_ester ( 2 ) , Roche_compound_3 ( 2 )

Downstream Regulation
Effects of modification on MEKK1:
enzymatic activity, induced ( 1 , 3 )

References 

1

Charlaftis N, et al. (2014) The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines. EMBO J 33, 2581-96
25260751   Curated Info

2

Siow YL, et al. (1997) Identification of two essential phosphorylated threonine residues in the catalytic domain of Mekk1. Indirect activation by Pak3 and protein kinase C. J Biol Chem 272, 7586-94
9065412   Curated Info

3

Deak JC, Templeton DJ (1997) Regulation of the activity of MEK kinase 1 (MEKK1) by autophosphorylation within the kinase activation domain. Biochem J 322 ( Pt 1), 185-92
9078260   Curated Info