Ser1276
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Home > Phosphorylation Site Page: > Ser1276  -  ERCC6 (human)

Site Information
DAIMDGAsPDyVLVE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 31874464

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 2 , 3 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
bone cancer ( 1 ) , colorectal cancer ( 1 ) , colorectal carcinoma ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
CDK1 (human) ( 1 )
Treatments:
CGP74514A ( 1 ) , thymidine ( 1 )

Downstream Regulation
Effects of modification on ERCC6:
intracellular localization ( 1 ) , molecular association, regulation ( 1 )
Effects of modification on biological processes:
DNA repair, altered ( 1 )
Induce interaction with:
BRCA1 (human) ( 1 )

References 

1

Batenburg NL, et al. (2019) CSB interacts with BRCA1 in late S/G2 to promote MRN- and CtIP-mediated DNA end resection. Nucleic Acids Res
31501894   Curated Info

2

Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94
25159151   Curated Info

3

Kettenbach AN, et al. (2011) Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells. Sci Signal 4, rs5
21712546   Curated Info