Thr85
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Home > Phosphorylation Site Page: > Thr85  -  CAMKK2 (human)

Site Information
GQEVPLDtSGSQARP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 31873289

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 , 3 ) , mutation of modification site ( 2 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:
COS (fibroblast) ( 2 ) , HeLa (cervical) ( 3 )

Upstream Regulation
Putative in vivo kinases:
CAMKK2 (human) ( 1 )
Kinases, in vitro:
CAMKK2 (human) ( 1 , 2 )
Treatments:
ionomycin ( 2 ) , lithium ( 2 )

Downstream Regulation
Effects of modification on CAMKK2:
enzymatic activity, induced ( 1 , 2 ) , phosphorylation ( 1 )
Effects of modification on biological processes:
signaling pathway regulation ( 1 )

References 

1

Xy Ling N, et al. (2020) Functional analysis of an R311C variant of Ca -calmodulin dependent protein kinase kinase-2 (CaMKK2) found as a de novo mutation in a patient with bipolar disorder. Bipolar Disord
32216002   Curated Info

2

Scott JW, et al. (2015) Autophosphorylation of CaMKK2 generates autonomous activity that is disrupted by a T85S mutation linked to anxiety and bipolar disorder. Sci Rep 5, 14436
26395653   Curated Info

3

Kettenbach AN, et al. (2011) Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells. Sci Signal 4, rs5
21712546   Curated Info

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