Lys464

Site Information
TLECILYkAEGAPPQ SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 31839903

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:	breast cancer ( 1 )
Relevant cell line - cell type - tissue:	COS7 (fibroblast) ( 1 ) , HeLa (cervical) ( 1 ) , MDA-MB-231 (breast cell) ( 1 ) , T47D (breast cell) ( 1 )

Downstream Regulation
Effects of modification on PR:	molecular association, regulation ( 1 )
Effects of modification on biological processes:	cell adhesion, induced ( 1 ) , transcription, induced ( 1 )
Induce interaction with:	N-CoR1 (human) ( 1 ) , SMRT (human) ( 1 )

References
1	Chung HH, et al. (2014) Lysine Methylation of Progesterone Receptor at Activation Function 1 Regulates both Ligand-independent Activity and Ligand Sensitivity of the Receptor. J Biol Chem 289, 5704-22 24415758 Curated Info