Ser332
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Home > Phosphorylation Site Page: > Ser332  -  CAMK2A iso2 (human)

Site Information
DGVKkRKsssSVQLM   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 3143902

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 ) , mutation of modification site ( 1 , 3 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
Alzheimer's disease ( 2 ) , neuroblastoma ( 1 )
Relevant cell line - cell type - tissue:
'brain, cerebral cortex' ( 2 ) , COS (fibroblast) ( 3 ) , Neuro-2a (neuron) ( 1 ) , neuron ( 1 )

Upstream Regulation
Kinases, in vitro:
CAMK1A (human) ( 3 ) , CAMK4 (human) ( 3 )
Phosphatases, in vitro:
PPP1CA (human) ( 1 )

Downstream Regulation
Effects of modification on CAMK2A iso2:
intracellular localization ( 3 )

References 

1

Shioda N, et al. (2015) Nuclear Translocation of Calcium/Calmodulin-dependent Protein Kinase II╬┤3 Promoted by Protein Phosphatase-1 Enhances Brain-derived Neurotrophic Factor Expression in Dopaminergic Neurons. J Biol Chem 290, 21663-75
26163515   Curated Info

2

Xia Q, et al. (2008) Phosphoproteomic analysis of human brain by calcium phosphate precipitation and mass spectrometry. J Proteome Res 7, 2845-51
18510355   Curated Info

3

Heist EK, Srinivasan M, Schulman H (1998) Phosphorylation at the nuclear localization signal of Ca2+/calmodulin-dependent protein kinase II blocks its nuclear targeting. J Biol Chem 273, 19763-71
9677407   Curated Info