Thr306
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Home > Phosphorylation Site Page: > Thr306  -  CAMK2A iso2 (human)

Site Information
LKGAILttMLATRNF   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449596

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry (in vitro) ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
neuroblastoma ( 1 )
Relevant cell line - cell type - tissue:
'brain, hippocampus' ( 1 ) , HEK293T (epithelial) ( 1 ) , SH-SY5Y (neural crest) ( 1 )

Upstream Regulation
Putative upstream phosphatases:
PTEN (human) ( 1 )
Phosphatases, in vitro:
PTEN (human) ( 1 )

Downstream Regulation
Effects of modification on CAMK2A iso2:
enzymatic activity, inhibited ( 1 ) , intracellular localization ( 1 ) , molecular association, regulation ( 1 ) , phosphorylation ( 1 )
Inhibit interaction with:
NMDAR2B (human) ( 1 )

References 

1

Wang P, et al. (2017) PTENĪ± Modulates CaMKII Signaling and Controls Contextual Fear Memory and Spatial Learning. Cell Rep 19, 2627-2641
28636948   Curated Info