Ser159
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Home > Phosphorylation Site Page: > Ser159  -  CDK5 (human)

Site Information
GIPVRCYsAEVVTLW   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448021

In vivo Characterization
Methods used to characterize site in vivo:
phospho-antibody ( 2 ) , western blotting ( 2 )
Disease tissue studied:
liver cancer ( 2 ) , neuroblastoma ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Kinases, in vitro:
CK1A (human) ( 3 )
Treatments:
CXCL12 ( 1 ) , luteolin ( 2 ) , seliciclib ( 2 )

Downstream Regulation
Effects of modification on CDK5:
enzymatic activity, induced ( 3 )

References 

1

Varrin-Doyer M, et al. (2009) Phosphorylation of Collapsin Response Mediator Protein 2 on Tyr-479 Regulates CXCL12-induced T Lymphocyte Migration. J Biol Chem 284, 13265-76
19276087   Curated Info

2

Selvendiran K, et al. (2006) Luteolin promotes degradation in signal transducer and activator of transcription 3 in human hepatoma cells: an implication for the antitumor potential of flavonoids. Cancer Res 66, 4826-34
16651438   Curated Info

3

Sharma P, et al. (1999) Regulation of cyclin-dependent kinase 5 catalytic activity by phosphorylation. Proc Natl Acad Sci U S A 96, 11156-60
10500146   Curated Info

4

Poon RY, Lew J, Hunter T (1997) Identification of functional domains in the neuronal Cdk5 activator protein. J Biol Chem 272, 5703-8
9038181   Curated Info