Lys138

Site Information
HtyRKGVkIDkTDYM SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 31089519

In vivo Characterization
Methods used to characterize site in vivo:	immunoprecipitation ( 1 ) , mass spectrometry ( 1 ) , modification-specific antibody ( 1 ) , mutation of modification site ( 3 ) , western blotting ( 1 )
Disease tissue studied:	colorectal cancer ( 3 ) , colorectal carcinoma ( 3 )
Relevant cell line - cell type - tissue:	293 (epithelial) ( 1 ) , E.coli (bacterial) ( 1 ) , HCT116 (intestinal) ( 3 )

Downstream Regulation
Effects of modification on RhoGDI alpha:	phosphorylation ( 3 )
Effects of modification on biological processes:	carcinogenesis, inhibited ( 3 ) , cell cycle regulation ( 3 ) , cell growth, inhibited ( 3 ) , signaling pathway regulation ( 3 ) , transcription, inhibited ( 3 )

References
1	Kuhlmann N, et al. (2016) Structural and Mechanistic Insights into the Regulation of the Fundamental Rho Regulator RhoGDIα by Lysine Acetylation. J Biol Chem 291, 5484-99 26719334 Curated Info
2	Impens F, Radoshevich L, Cossart P, Ribet D (2014) Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli. Proc Natl Acad Sci U S A 111, 12432-7 25114211 Curated Info
3	Cao Z, et al. (2014) SUMOylation of RhoGDIα is required for its repression of cyclin D1 expression and anchorage-independent growth of cancer cells. Mol Oncol 8, 285-96 24342356 Curated Info