Thr226
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Home > Phosphorylation Site Page: > Thr226  -  G3BP-2 (human)

Site Information
EELEEKsttPPPAEP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 3072179

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 2 , 3 , 4 , 5 , 6 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
colorectal cancer ( 1 ) , colorectal carcinoma ( 1 ) , lung cancer ( 2 ) , non-small cell lung adenocarcinoma ( 2 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 5 ) , HCT116 (intestinal) ( 1 ) , HEK293T (epithelial) ( 1 ) , HUES-7 ('stem, embryonic') ( 4 ) , Jurkat (T lymphocyte) ( 6 ) , K562 (erythroid) ( 3 ) , LoVo (intestinal) ( 1 ) , lung ( 2 )

Upstream Regulation
Putative in vivo kinases:
RIOK1 (human) ( 1 )
Treatments:
siRNA ( 1 ) , TBB ( 1 ) , toyocamycin ( 1 )

Downstream Regulation
Effects of modification on G3BP-2:
ubiquitination ( 1 )
Effects of modification on biological processes:
apoptosis, inhibited ( 1 ) , carcinogenesis, induced ( 1 )

References 

1

Chen Y, et al. (2022) RIOK1 mediates p53 degradation and radioresistance in colorectal cancer through phosphorylation of G3BP2. Oncogene
35589951   Curated Info

2

Schweppe DK, Rigas JR, Gerber SA (2013) Quantitative phosphoproteomic profiling of human non-small cell lung cancer tumors. J Proteomics 91, 286-96
23911959   Curated Info

3

Zhou H, et al. (2013) Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res 12, 260-71
23186163   Curated Info

4

Van Hoof D, et al. (2009) Phosphorylation dynamics during early differentiation of human embryonic stem cells. Cell Stem Cell 5, 214-26
19664995   Curated Info

5

Gauci S, et al. (2009) Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem 81, 4493-501
19413330   Curated Info

6

Ficarro SB, et al. (2005) Automated immobilized metal affinity chromatography/nano-liquid chromatography/electrospray ionization mass spectrometry platform for profiling protein phosphorylation sites. Rapid Commun Mass Spectrom 19, 57-71
15570572   Curated Info

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