Lys1191
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Home > Ubiquitylation Site Page: > Lys1191  -  HIPK2 (human)

Site Information
GYPLsPAkVNQYPyI   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 3059901

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 , 2 ) , western blotting ( 1 , 2 )
Disease tissue studied:
colorectal cancer ( 2 ) , colorectal carcinoma ( 2 ) , lung cancer ( 1 , 2 ) , non-small cell lung cancer ( 1 , 2 )
Relevant cell line - cell type - tissue:

Downstream Regulation
Effects of modification on HIPK2:
protein degradation ( 1 , 2 ) , ubiquitination ( 2 )

References 

1

Winter M, et al. (2008) Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR. Nat Cell Biol 10, 812-24
18536714   Curated Info

2

Rinaldo C, et al. (2007) MDM2-regulated degradation of HIPK2 prevents p53Ser46 phosphorylation and DNA damage-induced apoptosis. Mol Cell 25, 739-50
17349959   Curated Info