Ser190
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Home > Phosphorylation Site Page: > Ser190  -  PR (human)

Site Information
kVLPRGLsPARQLLL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447986

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 5 ) , immunoprecipitation ( 1 ) , mass spectrometry ( 3 ) , mutation of modification site ( 6 ) , phospho-antibody ( 1 , 2 , 4 ) , phosphopeptide mapping ( 5 ) , western blotting ( 1 , 2 , 6 )
Disease tissue studied:
breast cancer ( 2 ) , ovarian cancer ( 1 )
Relevant cell line - cell type - tissue:
COS (fibroblast) ( 6 ) , ES2 (ovarian) ( 1 ) , HeLa (cervical) ( 6 ) , SF9 ( 3 ) , T47D (breast cell) ( 2 , 4 , 5 )

Upstream Regulation
Kinases, in vitro:
CDK2 (human) ( 3 , 5 )
Treatments:
progestin_R5020 ( 1 , 2 , 3 , 4 , 5 )

Downstream Regulation
Effects of modification on biological processes:
transcription, induced ( 6 )

References 

1

Diep CH, Knutson TP, Lange CA (2016) Active FOXO1 Is a Key Determinant of Isoform-Specific Progesterone Receptor Transactivation and Senescence Programming. Mol Cancer Res 14, 141-62
26577046   Curated Info

2

Narayanan R, Edwards DP, Weigel NL (2005) Human progesterone receptor displays cell cycle-dependent changes in transcriptional activity. Mol Cell Biol 25, 2885-98
15798179   Curated Info

3

Knotts TA, et al. (2001) Identification of a phosphorylation site in the hinge region of the human progesterone receptor and additional amino-terminal phosphorylation sites. J Biol Chem 276, 8475-83
11110801   Curated Info

4

Clemm DL, et al. (2000) Differential hormone-dependent phosphorylation of progesterone receptor A and B forms revealed by a phosphoserine site-specific monoclonal antibody. Mol Endocrinol 14, 52-65
10628747   Curated Info

5

Zhang Y, et al. (1997) Phosphorylation of human progesterone receptor by cyclin-dependent kinase 2 on three sites that are authentic basal phosphorylation sites in vivo. Mol Endocrinol 11, 823-32
9171245   Curated Info

6

Takimoto GS, et al. (1996) Role of phosphorylation on DNA binding and transcriptional functions of human progesterone receptors. J Biol Chem 271, 13308-16
8662865   Curated Info

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