Ser67
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Home > Phosphorylation Site Page: > Ser67  -  MEKK1 (human)

Site Information
RQLRKVRsVELDQLP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 3053616

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 ) , mutation of modification site ( 2 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Disease tissue studied:
luminal A breast cancer ( 1 ) , luminal B breast cancer ( 1 ) , breast cancer, triple negative ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 2 ) , breast ( 1 )

Upstream Regulation
Kinases, in vitro:
PAK1 (human) ( 2 )
Phosphatases, in vitro:
PPP2CA (human) ( 2 )
Treatments:
anisomycin ( 2 ) , EGF ( 2 ) , IL-1a ( 2 ) , TNF ( 2 ) , UV ( 2 )

Downstream Regulation
Effects of modification on MEKK1:
molecular association, regulation ( 2 )
Inhibit interaction with:
JNK1 (human) ( 2 )

References 

1

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

2

Gallagher ED, et al. (2002) Binding of JNK/SAPK to MEKK1 is regulated by phosphorylation. J Biol Chem 277, 45785-92
12228228   Curated Info