Lys183
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Home > Acetylation Site Page: > Lys183  -  PR (human)

Site Information
SGTAAAHkVLPRGLs   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 30332700

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 1 ) , modification-specific antibody ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
breast cancer ( 1 )
Relevant cell line - cell type - tissue:
HeLa (cervical) ( 1 ) , MDA-MB-231 (breast cell) ( 1 )

Upstream Regulation
Treatments:
progestin_R5020 ( 1 ) , trichostatin_A ( 1 )

Downstream Regulation
Effects of modification on PR:
molecular association, regulation ( 1 ) , phosphorylation ( 1 )
Effects of modification on biological processes:
transcription, induced ( 1 )
Induce interaction with:
DNA ( 1 )

References 

1

Chung HH, Sze SK, Tay AS, Lin VC (2014) Acetylation at Lysine 183 of Progesterone Receptor by p300 Accelerates DNA Binding Kinetics and Transactivation of Direct Target Genes. J Biol Chem 289, 2180-94
24302725   Curated Info

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