Ser478
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Home > Phosphorylation Site Page: > Ser478  -  MCT1 iso4 (human)

Site Information
GGPKEEEsPV_____   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 468178

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 2 , 3 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 )
Disease tissue studied:
breast cancer ( 3 ) , lung cancer ( 1 , 3 ) , non-small cell lung cancer ( 3 ) , non-small cell lung adenocarcinoma ( 1 )
Relevant cell line - cell type - tissue:
'muscle, skeletal' ( 5 ) , HCC1937 (breast cell) ( 3 ) , HCC366 (pulmonary) ( 3 ) , HCC78 (pulmonary) ( 3 ) , HeLa (cervical) ( 2 , 8 , 10 , 13 ) , HeLa S3 (cervical) ( 6 , 11 , 12 ) , HeLa_Meta (cervical) ( 9 ) , HeLa_Pro (cervical) ( 9 ) , HeLa_Telo (cervical) ( 9 ) , HUES-9 ('stem, embryonic') ( 7 ) , K562 (erythroid) ( 2 , 10 ) , lung ( 1 ) , MCF-7 (breast cell) ( 3 ) , NCI-H1395 (pulmonary) ( 3 ) , NCI-H1568 (pulmonary) ( 3 ) , NCI-H2030 (pulmonary) ( 3 ) , NCI-H520 (squamous) ( 3 ) , NCI-H647 (pulmonary) ( 3 ) , PC9 (pulmonary) ( 3 )

Upstream Regulation
Treatments:
MG132 ( 9 )

References 

1

Schweppe DK, Rigas JR, Gerber SA (2013) Quantitative phosphoproteomic profiling of human non-small cell lung cancer tumors. J Proteomics 91, 286-96
23911959   Curated Info

2

Zhou H, et al. (2013) Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res 12, 260-71
23186163   Curated Info

3

Klammer M, et al. (2012) Phosphosignature predicts dasatinib response in non-small cell lung cancer. Mol Cell Proteomics 11, 651-68
22617229   Curated Info

4

Beli P, et al. (2012) Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response. Mol Cell 46, 212-25
22424773   Curated Info

5

Lundby A, et al. (2012) Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun 3, 876
22673903   Curated Info

6

Santamaria A, et al. (2011) The Plk1-dependent phosphoproteome of the early mitotic spindle. Mol Cell Proteomics 10, M110.004457
20860994   Curated Info

7

Rigbolt KT, et al. (2011) System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci Signal 4, rs3
21406692   Curated Info

8

Kettenbach AN, et al. (2011) Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells. Sci Signal 4, rs5
21712546   Curated Info

9

Dulla K, et al. (2010) Quantitative site-specific phosphorylation dynamics of human protein kinases during mitotic progression. Mol Cell Proteomics 9, 1167-81
20097925   Curated Info

10

Pan C, Olsen JV, Daub H, Mann M (2009) Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics. Mol Cell Proteomics 8, 2796-808
19651622   Curated Info

11

Malik R, et al. (2009) Quantitative analysis of the human spindle phosphoproteome at distinct mitotic stages. J Proteome Res 8, 4553-63
19691289   Curated Info

12

Daub H, et al. (2008) Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol Cell 31, 438-48
18691976   Curated Info

13

Dephoure N, et al. (2008) A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A 105, 10762-7
18669648   Curated Info