Lys379
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Home > Acetylation Site Page: > Lys379  -  p53 (mouse)

Site Information
QsTsRHkkTMVkkVG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 458977

In vivo Characterization
Methods used to characterize site in vivo:
modification-specific antibody ( 7 , 8 , 9 ) , mutation of modification site ( 7 , 8 , 9 ) , phospho-antibody ( 8 , 9 ) , western blotting ( 7 , 8 , 9 )
Disease tissue studied:
cancer, squamous cell carcinoma ( 8 )
Relevant cell line - cell type - tissue:
epidermal ( 8 ) , ES (stem) ( 9 ) , SF9 ( 7 )

Upstream Regulation
Regulatory protein:
p53 (mouse) ( 7 )
Treatments:
ionizing_radiation ( 8 ) , UV ( 8 , 9 )

References 

1

Nakazawa H, et al. (2017) iNOS as a Driver of Inflammation and Apoptosis in Mouse Skeletal Muscle after Burn Injury: Possible Involvement of Sirt1 S-Nitrosylation-Mediated Acetylation of p65 NF-κB and p53. PLoS One 12, e0170391
28099528   Curated Info

2

Clark-Knowles KV, et al. (2017) Reversible modulation of SIRT1 activity in a mouse strain. PLoS One 12, e0173002
28273169   Curated Info

3

Gagné-Sansfaçon J, et al. (2016) SHP-2 phosphatase contributes to KRAS-driven intestinal oncogenesis but prevents colitis-associated cancer development. Oncotarget 7, 65676-65695
27582544   Curated Info

4

Chen S, et al. (2015) Histone deacetylase 1 and 2 regulate Wnt and p53 pathways in the ureteric bud epithelium. Development 142, 1180-92
25758227   Curated Info

5

Warnock LJ, et al. (2008) Influence of tetramerisation on site-specific post-translational modifications of p53: comparison of human and murine p53 tumor suppressor protein. Cancer Biol Ther 7, 1481-9
18769132   Curated Info

6

Kurash JK, et al. (2008) Methylation of p53 by Set7/9 mediates p53 acetylation and activity in vivo. Mol Cell 29, 392-400
18280244   Curated Info

7

Warnock LJ, Raines SA, Mee TR, Milner J (2005) Role of phosphorylation in p53 acetylation and PAb421 epitope recognition in baculoviral and mammalian expressed proteins. FEBS J 272, 1669-75
15794754   Curated Info

8

Knights CD, Liu Y, Appella E, Kulesz-Martin M (2003) Defective p53 post-translational modification required for wild type p53 inactivation in malignant epithelial cells with mdm2 gene amplification. J Biol Chem 278, 52890-900
14555661   Curated Info

9

Chao C, et al. (2000) Phosphorylation of murine p53 at ser-18 regulates the p53 responses to DNA damage. Proc Natl Acad Sci U S A 97, 11936-41
11035798   Curated Info