Lys382
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Home > Acetylation Site Page: > Lys382  -  p53 (human)

Site Information
QstsRHkkLMFktEG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 458977

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 13 , 28 , 96 , 98 , 117 , 125 ) , mass spectrometry ( 77 , 91 , 135 ) , microscopy-colocalization with upstream kinase ( 13 ) , modification-specific antibody ( 22 , 55 , 69 , 72 , 111 , 117 , 118 ) , mutation of modification site ( 28 , 80 , 91 , 96 , 98 , 111 , 114 , 118 , 126 , 132 ) , phospho-antibody ( 13 , 22 , 35 , 69 , 101 , 117 , 118 , 125 ) , western blotting ( 13 , 22 , 35 , 55 , 69 , 72 , 96 , 98 , 101 , 111 , 117 , 118 , 125 )
Disease tissue studied:
ataxia-telangiectasia ( 125 ) , bone cancer ( 13 , 28 , 72 , 96 , 101 ) , breast cancer ( 126 ) , colorectal cancer ( 35 , 55 , 91 , 98 , 114 , 117 , 118 ) , colorectal carcinoma ( 35 , 55 , 91 , 98 , 114 , 117 , 118 ) , eye cancer ( 69 ) , retinoblastoma ( 69 ) , leukemia ( 135 ) , acute myelogenous leukemia ( 135 ) , lung cancer ( 13 , 80 , 91 , 96 , 118 , 125 , 132 ) , non-small cell lung cancer ( 13 , 80 , 91 , 96 , 118 , 132 ) , melanoma skin cancer ( 98 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
DYRK1A (human) ( 72 ) , DYRK3 (human) ( 72 ) , MDM2 (human) ( 101 ) , p53 (human) ( 125 ) , PHF1 (human) ( 50 ) , PML iso4 (human) ( 124 ) , RASSF5 (human) ( 22 ) , TWIST1 (human) ( 55 )
Treatments:
adriamycin ( 13 , 101 , 118 ) , DDATHF ( 117 ) , depsipeptide ( 69 ) , etoposide ( 50 , 72 , 98 , 117 ) , ionizing_radiation ( 51 , 69 , 118 , 125 , 128 ) , MS275 ( 77 ) , nicotinamide ( 91 ) , nocodazole ( 118 ) , osmotic_stress ( 128 ) , PALA ( 118 ) , SB203580 ( 128 ) , siRNA ( 101 ) , taxol ( 118 ) , trichostatin_A ( 41 , 91 , 96 ) , UV ( 96 , 98 , 118 , 125 ) , valproic_acid ( 69 ) , vorinostat ( 77 )

Downstream Regulation
Effects of modification on p53:
activity, induced ( 124 ) , molecular association, regulation ( 96 ) , protein degradation ( 126 , 132 ) , protein stabilization ( 124 ) , ubiquitination ( 132 )
Effects of modification on biological processes:
apoptosis, induced ( 71 , 86 , 91 , 114 ) , cell growth, induced ( 126 ) , cell growth, inhibited ( 124 ) , transcription, altered ( 80 , 91 , 114 ) , transcription, induced ( 71 , 86 , 96 , 124 )
Induce interaction with:
DNA ( 96 ) , TAF1 (human) ( 96 )

References 

1

Zheng S, et al. (2017) Inhibiting p53 Acetylation Reduces Cancer Chemotoxicity. Cancer Res 77, 4342-4354
28655792   Curated Info

2

Calapre L, et al. (2017) SIRT1 activation mediates heat-induced survival of UVB damaged Keratinocytes. BMC Dermatol 17, 8
28601088   Curated Info

3

Xu L, et al. (2017) BCL6 promotes glioma and serves as a therapeutic target. Proc Natl Acad Sci U S A 114, 3981-3986
28356518   Curated Info

4

Ryu HW, et al. (2017) HDAC6 deacetylates p53 at lysines 381/382 and differentially coordinates p53-induced apoptosis. Cancer Lett 391, 162-171
28153791   Curated Info

5

Yuan H, et al. (2017) Tenovin-6 inhibits proliferation and survival of diffuse large B-cell lymphoma cells by blocking autophagy. Oncotarget 8, 14912-14924
28118604   Curated Info

6

Wang G, et al. (2017) Loss of BRG1 induces CRC cell senescence by regulating p53/p21 pathway. Cell Death Dis 8, e2607
28182012   Curated Info

7

Ferrer CM, et al. (2017) O-GlcNAcylation regulates breast cancer metastasis via SIRT1 modulation of FOXM1 pathway. Oncogene 36, 559-569
27345396   Curated Info

8

Bao L, et al. (2016) Histone deacetylase inhibitor induces cell apoptosis and cycle arrest in lung cancer cells via mitochondrial injury and p53 up-acetylation. Cell Biol Toxicol 32, 469-482
27423454   Curated Info

9

Choi OR, Ryu MS, Lim IK (2016) Shifting p53-induced senescence to cell death by TIS21(/BTG2/Pc3) gene through posttranslational modification of p53 protein. Cell Signal 28, 1172-85
27208501   Curated Info

10

de Queiroz RM, et al. (2016) Changes in O-Linked N-Acetylglucosamine (O-GlcNAc) Homeostasis Activate the p53 Pathway in Ovarian Cancer Cells. J Biol Chem 291, 18897-914
27402830   Curated Info

11

Knyphausen P, et al. (2016) Insights into Lysine Deacetylation of Natively Folded Substrate Proteins by Sirtuins. J Biol Chem 291, 14677-94
27226597   Curated Info

12

Sriraman A, et al. (2016) Cooperation of Nutlin-3a and a Wip1 inhibitor to induce p53 activity. Oncotarget 7, 31623-38
27183917   Curated Info

13

Conrad E, et al. (2016) HIPK2 restricts SIRT1 activity upon severe DNA damage by a phosphorylation-controlled mechanism. Cell Death Differ 23, 110-22
26113041   Curated Info

14

Zheng YC, et al. (2016) 1,2,3-Triazole-Dithiocarbamate Hybrids, a Group of Novel Cell Active SIRT1 Inhibitors. Cell Physiol Biochem 38, 185-93
26784898   Curated Info

15

Park JB (2016) Finding Potent Sirt Inhibitor in Coffee: Isolation, Confirmation and Synthesis of Javamide-II (N-Caffeoyltryptophan) as Sirt1/2 Inhibitor. PLoS One 11, e0150392
26986569   Curated Info

16

Phang BH, et al. (2015) Amino-terminal p53 mutations lead to expression of apoptosis proficient p47 and prognosticate better survival, but predispose to tumorigenesis. Proc Natl Acad Sci U S A 112, E6349-58
26578795   Curated Info

17

Agarwal S, Bell CM, Rothbart SB, Moran RG (2015) AMP-activated Protein Kinase (AMPK) Control of mTORC1 Is p53- and TSC2-independent in Pemetrexed-treated Carcinoma Cells. J Biol Chem 290, 27473-86
26391395   Curated Info

18

Qi J, et al. (2015) HDAC8 Inhibition Specifically Targets Inv(16) Acute Myeloid Leukemic Stem Cells by Restoring p53 Acetylation. Cell Stem Cell 17, 597-610
26387755   Curated Info

19

Lee WY, et al. (2015) Repositioning antipsychotic chlorpromazine for treating colorectal cancer by inhibiting sirtuin 1. Oncotarget 6, 27580-95
26363315   Curated Info

20

Seo SK, et al. (2015) Selective inhibition of histone deacetylase 2 induces p53-dependent survivin downregulation through MDM2 proteasomal degradation. Oncotarget 6, 26528-40
25605253   Curated Info

21

Zhao B, et al. (2015) Connexin32 regulates hepatoma cell metastasis and proliferation via the p53 and Akt pathways. Oncotarget 6, 10116-33
25426556   Curated Info

22

Donninger H, et al. (2015) NORE1A is a Ras senescence effector that controls the apoptotic/senescent balance of p53 via HIPK2. J Cell Biol 208, 777-89
25778922   Curated Info

23

Choi HK, et al. (2015) Programmed cell death 5 mediates HDAC3 decay to promote genotoxic stress response. Nat Commun 6, 7390
26077467   Curated Info

24

Kovalev RA, et al. (2015) [Histone deacetylase inhibitors cause the TP53-dependent induction of p21/Waf1 in tumor cells carrying mutations in TP53]. Tsitologiia 57, 204-11
26021170   Curated Info

25

Zhang E, et al. (2015) Metformin and Resveratrol Inhibited High Glucose-Induced Metabolic Memory of Endothelial Senescence through SIRT1/p300/p53/p21 Pathway. PLoS One 10, e0143814
26629991   Curated Info

26

Sutendra G, et al. (2014) A Nuclear Pyruvate Dehydrogenase Complex Is Important for the Generation of Acetyl-CoA and Histone Acetylation. Cell 158, 84-97
24995980   Curated Info

27

Liu L, et al. (2014) Exogenous NAD(+) supplementation protects H9c2 cardiac myoblasts against hypoxia/reoxygenation injury via Sirt1-p53 pathway. Fundam Clin Pharmacol 28, 180-9
23384296   Curated Info

28

Wu Y, et al. (2014) Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response. Mol Cell 53, 63-74
24289924   Curated Info

29

Zhang ZN, Chung SK, Xu Z, Xu Y (2014) Oct4 maintains the pluripotency of human embryonic stem cells by inactivating p53 through Sirt1-mediated deacetylation. Stem Cells 32, 157-65
24038750   Curated Info

30

Lau AW, Liu P, Inuzuka H, Gao D (2014) SIRT1 phosphorylation by AMP-activated protein kinase regulates p53 acetylation. Am J Cancer Res 4, 245-55
24959379   Curated Info

31

Shan X, et al. (2014) Ginsenoside Rg3 Inhibits Melanoma Cell Proliferation through Down-Regulation of Histone Deacetylase 3 (HDAC3) and Increase of p53 Acetylation. PLoS One 9, e115401
25521755   Curated Info

32

Chang J, et al. (2013) Acetylation of p53 stimulates miRNA processing and determines cell survival following genotoxic stress. EMBO J 32, 3192-205
24219989   Curated Info

33

Zheng H, et al. (2013) hMOF acetylation of DBC1/CCAR2 prevents binding and inhibition of SirT1. Mol Cell Biol 33, 4960-70
24126058   Curated Info

34

Wu J, et al. (2013) The up-regulation of histone deacetylase 8 promotes proliferation and inhibits apoptosis in hepatocellular carcinoma. Dig Dis Sci 58, 3545-53
24077923   Curated Info

35

Sen N, Kumari R, Singh MI, Das S (2013) HDAC5, a key component in temporal regulation of p53-mediated transactivation in response to genotoxic stress. Mol Cell 52, 406-20
24120667   Curated Info

36

Kim SS, Benchimol S (2013) HDAC5--a critical player in the p53 acetylation network. Mol Cell 52, 289-90
24207022   Curated Info

37

Yi G, et al. (2013) Low concentration of metformin induces a p53-dependent senescence in hepatoma cells via activation of the AMPK pathway. Int J Oncol 43, 1503-10
23982736   Curated Info

38

Mellini P, et al. (2013) Screen of pseudopeptidic inhibitors of human sirtuins 1-3: two lead compounds with antiproliferative effects in cancer cells. J Med Chem 56, 6681-95
23927550   Curated Info

39

Jin H, et al. (2013) HDAC inhibitor DWP0016 activates p53 transcription and acetylation to inhibit cell growth in U251 glioblastoma cells. J Cell Biochem 114, 1498-509
23297003   Curated Info

40

Liu N, et al. (2013) ING5 Is a Tip60 Cofactor That Acetylates p53 in Response to DNA Damage. Cancer Res 73, 3749-60
23576563   Curated Info

41

Brochier C, et al. (2013) Specific acetylation of p53 by HDAC inhibition prevents DNA damage-induced apoptosis in neurons. J Neurosci 33, 8621-32
23678107   Curated Info

42

Armour SM, et al. (2013) A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex. Mol Cell Biol 33, 1487-502
23382074   Curated Info

43

van Leeuwen IM, et al. (2013) Modulation of p53 C-Terminal Acetylation by mdm2, p14ARF, and Cytoplasmic SirT2. Mol Cancer Ther 12, 471-80
23416275   Curated Info

44

Kim MK, et al. (2013) Regulation of the Cyclin-dependent Kinase Inhibitor 1A Gene (CDKN1A) by the Repressor BOZF1 through Inhibition of p53 Acetylation and Transcription Factor Sp1 Binding. J Biol Chem 288, 7053-64
23329847   Curated Info

45

Rokudai S, et al. (2013) MOZ increases p53 acetylation and premature senescence through its complex formation with PML. Proc Natl Acad Sci U S A 110, 3895-900
23431171   Curated Info

46

Xu S, et al. (2013) hSSB1 regulates both the stability and the transcriptional activity of p53. Cell Res 23, 423-35
23184057   Curated Info

47

Thakur BK, et al. (2013) Involvement of p53 in the cytotoxic activity of the NAMPT inhibitor FK866 in myeloid leukemic cells. Int J Cancer 132, 766-74
22815158   Curated Info

48

Chan C, et al. (2013) Altered Binding Site Selection of p53 Transcription Cassettes by Hepatitis B Virus X Protein. Mol Cell Biol 33, 485-97
23149944   Curated Info

49

Wu D, et al. (2013) Runt-related Transcription Factor 1 (RUNX1) Stimulates Tumor Suppressor p53 Protein in Response to DNA Damage through Complex Formation and Acetylation. J Biol Chem 288, 1353-64
23148227   Curated Info

50

Yang Y, et al. (2013) Polycomb Group Protein PHF1 Regulates p53-dependent Cell Growth Arrest and Apoptosis. J Biol Chem 288, 529-39
23150668   Curated Info

51

Shahar OD, et al. (2013) acetylation of lysine 382 and phosphorylation of serine 392 in p53 modulate the interaction between p53 and MDC1 in vitro. PLoS One 8, e78472
24194938   Curated Info

52

Bursać S, et al. (2012) Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress. Proc Natl Acad Sci U S A 109, 20467-72
23169665   Curated Info

53

Liu L, et al. (2012) Variant 1 of KIAA0101, overexpressed in hepatocellular carcinoma, prevents doxorubicin-induced apoptosis by inhibiting p53 activation. Hepatology 56, 1760-9
22576474   Curated Info

54

Kim K, et al. (2012) Functional interplay between p53 acetylation and H1.2 phosphorylation in p53-regulated transcription. Oncogene 31, 4290-301
22249259   Curated Info

55

Piccinin S, et al. (2012) A "Twist box" Code of p53 Inactivation: Twist box:p53 Interaction Promotes p53 Degradation. Cancer Cell 22, 404-15
22975381   Curated Info

56

Lee CW, et al. (2012) AMPK Promotes p53 Acetylation via Phosphorylation and Inactivation of SIRT1 in Liver Cancer Cells. Cancer Res 72, 4394-404
22728651   Curated Info

57

Mahata B, Sundqvist A, Xirodimas DP (2012) Recruitment of RPL11 at promoter sites of p53-regulated genes upon nucleolar stress through NEDD8 and in an Mdm2-dependent manner. Oncogene 31, 3060-71
22081073   Curated Info

58

Kim WJ, Rivera MN, Coffman EJ, Haber DA (2012) The WTX tumor suppressor enhances p53 acetylation by CBP/p300. Mol Cell 45, 587-97
22285752   Curated Info

59

Wang H, et al. (2012) The HDAC inhibitor depsipeptide transactivates the p53/p21 pathway by inducing DNA damage. DNA Repair (Amst) 11, 146-56
22112863   Curated Info

60

Illuzzi JL, Vickers CA, Kmiec EB (2011) Modifications of p53 and the DNA damage response in cells expressing mutant form of the protein huntingtin. J Mol Neurosci 45, 256-68
21465263   Curated Info

61

Xu S, et al. (2011) High-fat diet increases and the polyphenol, S17834, decreases acetylation of the sirtuin-1-dependent lysine-382 on p53 and apoptotic signaling in atherosclerotic lesion-prone aortic endothelium of normal mice. J Cardiovasc Pharmacol 58, 263-71
21654327   Curated Info

62

Bug M, Dobbelstein M (2011) Anthracyclines induce the accumulation of mutant p53 through E2F1-dependent and -independent mechanisms. Oncogene 30, 3612-24
21441950   Curated Info

63

Seo SK, et al. (2011) Histone deacetylase inhibitors sensitize human non-small cell lung cancer cells to ionizing radiation through acetyl p53-mediated c-myc down-regulation. J Thorac Oncol 6, 1313-9
21642861   Curated Info

64

Debnath S, et al. (2011) Peptide-protein interactions suggest that acetylation of lysines 381 and 382 of p53 is important for positive coactivator 4-p53 interaction. J Biol Chem 286, 25076-87
21586571   Curated Info

65

Savelyeva I, Dobbelstein M (2011) Infection with E1B-mutant adenovirus stabilizes p53 but blocks p53 acetylation and activity through E1A. Oncogene 30, 865-75
20935676   Curated Info

66

Mellert HS, et al. (2011) Deacetylation of the DNA-binding domain regulates p53-mediated apoptosis. J Biol Chem 286, 4264-70
21148320   Curated Info

67

Robers MB, et al. (2011) Measurement of the cellular deacetylase activity of SIRT1 on p53 via LanthaScreen® technology. Mol Biosyst 7, 59-66
20931131   Curated Info

68

Aranha MM, et al. (2011) miR-34a regulates mouse neural stem cell differentiation. PLoS One 6, e21396
21857907   Curated Info

69

Kawano T, et al. (2010) Histone deacetylase inhibitors valproic acid and depsipeptide sensitize retinoblastoma cells to radiotherapy by increasing H2AX phosphorylation and p53 acetylation-phosphorylation. Int J Oncol 37, 787-95
20811699   Curated Info

70

Puca R, Nardinocchi L, Givol D, D'Orazi G (2010) Regulation of p53 activity by HIPK2: molecular mechanisms and therapeutical implications in human cancer cells. Oncogene 29, 4378-87
20514025   Curated Info

71

Puca R, et al. (2010) Nox1 is involved in p53 deacetylation and suppression of its transcriptional activity and apoptosis. Free Radic Biol Med 48, 1338-46
20171273   Curated Info

72

Guo X, Williams JG, Schug TT, Li X (2010) DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1. J Biol Chem 285, 13223-32
20167603   Curated Info

73

Eichenbaum KD, Rodríguez Y, Mezei M, Osman R (2010) The energetics of the acetylation switch in p53-mediated transcriptional activation. Proteins 78, 447-56
19731376   Curated Info

74

Nishimura T, et al. (2009) Hepatitis C virus impairs p53 via persistent overexpression of 3beta-hydroxysterol Delta24-reductase. J Biol Chem 284, 36442-52
19861417   Curated Info

75

van Dieck J, et al. (2009) Posttranslational modifications affect the interaction of S100 proteins with tumor suppressor p53. J Mol Biol 394, 922-30
19819244   Curated Info

76

Yadavilli S, Chen Z, Albrecht T, Muganda PM (2009) Mechanism of diepoxybutane-induced p53 regulation in human cells. J Biochem Mol Toxicol 23, 373-86
20024960   Curated Info

77

Choudhary C, et al. (2009) Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science 325, 834-40
19608861   Curated Info

78

Pavithra L, et al. (2009) SMAR1 forms a ternary complex with p53-MDM2 and negatively regulates p53-mediated transcription. J Mol Biol 388, 691-702
19303885   Curated Info

79

Wu SY, Chiang CM (2009) Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding. EMBO J 28, 1246-59
19339993   Curated Info

80

Tian C, et al. (2009) KRAB-type zinc-finger protein Apak specifically regulates p53-dependent apoptosis. Nat Cell Biol 11, 580-91
19377469   Curated Info

81

Yamaguchi H, et al. (2009) p53 Acetylation Is Crucial for Its Transcription-independent Proapoptotic Functions. J Biol Chem 284, 11171-83
19265193   Curated Info

82

Allison SJ, Jiang M, Milner J (2009) Oncogenic viral protein HPV E7 up-regulates the SIRT1 longevity protein in human cervical cancer cells. Aging (Albany NY) 1, 316-27
20157519   Curated Info

83

Itahana Y, Ke H, Zhang Y (2009) p53 Oligomerization is essential for its C-terminal lysine acetylation. J Biol Chem 284, 5158-64
19106109   Curated Info

84

Zhu Z, et al. (2009) Human inhibitor of growth 1 inhibits hepatoma cell growth and influences p53 stability in a variant-dependent manner. Hepatology 49, 504-12
19085961   Curated Info

85

Kang H, Jung JW, Kim MK, Chung JH (2009) CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damage. PLoS One 4, e6611
19680552   Curated Info

86

Puca R, et al. (2009) HIPK2 modulates p53 activity towards pro-apoptotic transcription. Mol Cancer 8, 85
19828042   Curated Info

87

Xenaki G, et al. (2008) PCAF is an HIF-1alpha cofactor that regulates p53 transcriptional activity in hypoxia. Oncogene 27, 5785-96
18574470   Curated Info

88

Warnock LJ, et al. (2008) Influence of tetramerisation on site-specific post-translational modifications of p53: comparison of human and murine p53 tumor suppressor protein. Cancer Biol Ther 7, 1481-9
18769132   Curated Info

89

Chen JJ, Chou CW, Chang YF, Chen CC (2008) Proteasome inhibitors enhance TRAIL-induced apoptosis through the intronic regulation of DR5: involvement of NF-kappaB and reactive oxygen species-mediated p53 activation. J Immunol 180, 8030-9
18523266   Curated Info

90

Lin T, Mak NK, Yang MS (2008) MAPK regulate p53-dependent cell death induced by benzo[a]pyrene: Involvement of p53 phosphorylation and acetylation. Toxicology 247, 145-53
18406507   Curated Info

91

Tang Y, et al. (2008) Acetylation is indispensable for p53 activation. Cell 133, 612-26
18485870   Curated Info

92

Habold C, et al. (2008) Trichostatin A causes p53 to switch oxidative-damaged colorectal cancer cells from cell cycle arrest into apoptosis. J Cell Mol Med 12, 607-21
18419600   Curated Info

93

Warnock LJ, Adamson R, Lynch CJ, Milner J (2008) Crosstalk between site-specific modifications on p53 and histone H3. Oncogene 27, 1639-44
17891183   Curated Info

94

Wang H, et al. (2008) An ATM- and Rad3-related (ATR) Signaling Pathway and a Phosphorylation-Acetylation Cascade Are Involved in Activation of p53/p21Waf1/Cip1 in Response to 5-Aza-2'-deoxycytidine Treatment. J Biol Chem 283, 2564-74
17977830   Curated Info

95

Kitagawa M, Lee SH, McCormick F (2008) Skp2 suppresses p53-dependent apoptosis by inhibiting p300. Mol Cell 29, 217-31
18243116   Curated Info

96

Li AG, et al. (2007) An acetylation switch in p53 mediates holo-TFIID recruitment. Mol Cell 28, 408-21
17996705   Curated Info

97

Wong S, Weber JD (2007) Deacetylation of the retinoblastoma tumour suppressor protein by SIRT1. Biochem J 407, 451-60
17620057   Curated Info

98

Mantovani F, et al. (2007) The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP. Nat Struct Mol Biol 14, 912-20
17906639   Curated Info

99

Ivanov GS, et al. (2007) Methylation-acetylation interplay activates p53 in response to DNA damage. Mol Cell Biol 27, 6756-69
17646389   Curated Info

100

Shi X, et al. (2007) Modulation of p53 function by SET8-mediated methylation at lysine 382. Mol Cell 27, 636-46
17707234   Curated Info

101

Giono LE, Manfredi JJ (2007) Mdm2 is required for inhibition of Cdk2 activity by p21, thereby contributing to p53-dependent cell cycle arrest. Mol Cell Biol 27, 4166-78
17371838   Curated Info

102

Higashitsuji H, et al. (2007) Enhanced deacetylation of p53 by the anti-apoptotic protein HSCO in association with histone deacetylase 1. J Biol Chem 282, 13716-25
17353187   Curated Info

103

Nag A, et al. (2007) An essential role of human Ada3 in p53 acetylation. J Biol Chem 282, 8812-20
17272277   Curated Info

104

Roy S, Tenniswood M (2007) Site-specific acetylation of p53 directs selective transcription complex assembly. J Biol Chem 282, 4765-71
17121856   Curated Info

105

Singh K, et al. (2007) p53 target gene SMAR1 is dysregulated in breast cancer: its role in cancer cell migration and invasion. PLoS One 2, e660
17668048   Curated Info

106

Li AG, et al. (2006) Mechanistic insights into maintenance of high p53 acetylation by PTEN. Mol Cell 23, 575-87
16916644   Curated Info

107

Zhao Y, et al. (2006) Acetylation of p53 at lysine 373/382 by the histone deacetylase inhibitor depsipeptide induces expression of p21(Waf1/Cip1). Mol Cell Biol 26, 2782-90
16537920   Curated Info

108

Kawaguchi Y, Ito A, Appella E, Yao TP (2006) Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking. J Biol Chem 281, 1394-400
16291740   Curated Info

109

Sachchidanand, et al. (2006) Target structure-based discovery of small molecules that block human p53 and CREB binding protein association. Chem Biol 13, 81-90
16426974   Curated Info

110

Roy S, Packman K, Jeffrey R, Tenniswood M (2005) Histone deacetylase inhibitors differentially stabilize acetylated p53 and induce cell cycle arrest or apoptosis in prostate cancer cells. Cell Death Differ 12, 482-91
15746940   Curated Info

111

Warnock LJ, Raines SA, Mee TR, Milner J (2005) Role of phosphorylation in p53 acetylation and PAb421 epitope recognition in baculoviral and mammalian expressed proteins. FEBS J 272, 1669-75
15794754   Curated Info

112

Vaghefi H, Neet KE (2004) Deacetylation of p53 after nerve growth factor treatment in PC12 cells as a post-translational modification mechanism of neurotrophin-induced tumor suppressor activation. Oncogene 23, 8078-87
15361854   Curated Info

113

Brunet A, et al. (2004) Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303, 2011-5
14976264   Curated Info

114

Kaeser MD, Pebernard S, Iggo RD (2004) Regulation of p53 stability and function in HCT116 colon cancer cells. J Biol Chem 279, 7598-605
14665630   Curated Info

115

Luo J, et al. (2004) Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo. Proc Natl Acad Sci U S A 101, 2259-64
14982997   Curated Info

116

Mujtaba S, et al. (2004) Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation. Mol Cell 13, 251-63
14759370   Curated Info

117

Bronder JL, Moran RG (2003) A defect in the p53 response pathway induced by de novo purine synthesis inhibition. J Biol Chem 278, 48861-71
14517211   Curated Info

118

Saito S, et al. (2003) Phosphorylation site interdependence of human p53 post-translational modifications in response to stress. J Biol Chem 278, 37536-44
12860987   Curated Info

119

Kataoka H, et al. (2003) ING1 represses transcription by direct DNA binding and through effects on p53. Cancer Res 63, 5785-92
14522900   Curated Info

120

Zeng L, et al. (2003) The role of p53 deacetylation in p21Waf1 regulation by laminar flow. J Biol Chem 278, 24594-9
12716906   Curated Info

121

Shiseki M, et al. (2003) p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity. Cancer Res 63, 2373-8
12750254   Curated Info

122

Li M, Luo J, Brooks CL, Gu W (2002) Acetylation of p53 inhibits its ubiquitination by Mdm2. J Biol Chem 277, 50607-11
12421820   Curated Info

123

Ito A, et al. (2002) MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation. EMBO J 21, 6236-45
12426395   Curated Info

124

Bischof O, et al. (2002) Deconstructing PML-induced premature senescence. EMBO J 21, 3358-69
12093737   Curated Info

125

Saito S, et al. (2002) ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiation. J Biol Chem 277, 12491-4
11875057   Curated Info

126

Nakamura S, Roth JA, Mukhopadhyay T (2002) Multiple lysine mutations in the C-terminus of p53 make it resistant to degradation mediated by MDM2 but not by human papillomavirus E6 and induce growth inhibition in MDM2-overexpressing cells. Oncogene 21, 2605-10
11971195   Curated Info

127

Hofmann TG, et al. (2002) Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2. Nat Cell Biol 4, 1-10
11740489   Curated Info

128

Kishi H, et al. (2001) Osmotic shock induces G1 arrest through p53 phosphorylation at Ser33 by activated p38MAPK without phosphorylation at Ser15 and Ser20. J Biol Chem 276, 39115-22
11495913   Curated Info

129

Vaziri H, et al. (2001) hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 107, 149-59
11672523   Curated Info

130

Nagashima M, et al. (2001) DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53. Proc Natl Acad Sci U S A 98, 9671-6
11481424   Curated Info

131

Ito A, et al. (2001) p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2. EMBO J 20, 1331-40
11250899   Curated Info

132

Nakamura S, Roth JA, Mukhopadhyay T (2000) Multiple lysine mutations in the C-terminal domain of p53 interfere with MDM2-dependent protein degradation and ubiquitination. Mol Cell Biol 20, 9391-8
11094089   Curated Info

133

Luo J, et al. (2000) Deacetylation of p53 modulates its effect on cell growth and apoptosis. Nature 408, 377-81
11099047   Curated Info

134

Pearson M, et al. (2000) PML regulates p53 acetylation and premature senescence induced by oncogenic Ras. Nature 406, 207-10
10910364   Curated Info

135

Abraham J, Kelly J, Thibault P, Benchimol S (2000) Post-translational modification of p53 protein in response to ionizing radiation analyzed by mass spectrometry. J Mol Biol 295, 853-64
10656795   Curated Info

136

Sakaguchi K, et al. (1998) DNA damage activates p53 through a phosphorylation-acetylation cascade. Genes Dev 12, 2831-41
9744860   Curated Info

137

Gu W, Roeder RG (1997) Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell 90, 595-606
9288740   Curated Info