Lys317
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Home > Acetylation Site Page: > Lys317  -  p53 (mouse)

Site Information
sAsPPQkkkPLDGEy   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 458976

In vivo Characterization
Methods used to characterize site in vivo:
modification-specific antibody ( 4 , 5 ) , mutation of modification site ( 4 , 5 ) , phospho-antibody ( 5 ) , western blotting ( 4 , 5 )
Relevant cell line - cell type - tissue:
ES (stem) ( 5 ) , intestine ( 4 ) , MEF (fibroblast) ( 4 ) , retinal-retina ( 4 ) , thymocyte-thymus ( 4 )

Upstream Regulation
Treatments:
adriamycin ( 4 ) , UV ( 5 )

Downstream Regulation
Effects of modification on biological processes:
apoptosis, inhibited ( 4 ) , transcription, altered ( 4 )

References 

1

Song L, et al. (2011) p85α mediates p53 K370 acetylation by p300 and regulates its promoter-specific transactivity in the cellular UVB response. Oncogene 30, 1360-71
21057544   Curated Info

2

Jenkins LM, et al. (2008) Quantitative proteomics analysis of the effects of ionizing radiation in wild type and p53 K317R knock-in mouse thymocytes. Mol Cell Proteomics 7, 716-27
18178582   Curated Info

3

Kurash JK, et al. (2008) Methylation of p53 by Set7/9 mediates p53 acetylation and activity in vivo. Mol Cell 29, 392-400
18280244   Curated Info

4

Chao C, et al. (2006) Acetylation of mouse p53 at lysine 317 negatively regulates p53 apoptotic activities after DNA damage. Mol Cell Biol 26, 6859-69
16943427   Curated Info

5

Chao C, et al. (2000) Phosphorylation of murine p53 at ser-18 regulates the p53 responses to DNA damage. Proc Natl Acad Sci U S A 97, 11936-41
11035798   Curated Info