Lys99

Site Information
RCLLWACkACkRkTT SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 458968

In vivo Characterization
Methods used to characterize site in vivo:	3H acetate labeling ( 2 ) , [14C] acetate labeling ( 2 ) , immunoassay ( 2 ) , immunoprecipitation ( 2 ) , mutation of modification site ( 2 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:	3T3 (fibroblast) ( 2 ) , C2C12 (myoblast) ( 2 )

Downstream Regulation
Effects of modification on MyoD:	molecular association, regulation ( 1 , 2 ) , protein conformation ( 2 )
Effects of modification on biological processes:	cell differentiation, induced ( 2 ) , transcription, induced ( 2 )
Induce interaction with:	CBP (human) ( 1 ) , DNA ( 2 ) , p300 (human) ( 1 )

References
1	Wei L, et al. (2008) Differential binding modes of the bromodomains of CREB-binding protein (CBP) and p300 with acetylated MyoD. Biochem Biophys Res Commun 368, 279-84 18222173 Curated Info
2	Sartorelli V, et al. (1999) Acetylation of MyoD directed by PCAF is necessary for the execution of the muscle program. Mol Cell 4, 725-34 10619020 Curated Info