Lys631
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Home > Acetylation Site Page: > Lys631  -  AR (human)

Site Information
GMTLGARkLkkLGNL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 458906

In vivo Characterization
Methods used to characterize site in vivo:
3H acetate labeling ( 9 ) , immunoprecipitation ( 1 , 8 , 9 , 11 ) , mass spectrometry (in vitro) ( 11 ) , modification-specific antibody ( 11 ) , mutation of modification site ( 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 ) , western blotting ( 1 , 2 , 3 , 8 , 9 , 11 )
Disease tissue studied:
adrenal cancer ( 2 ) , pheochromocytoma ( 2 ) , prostate cancer ( 3 , 4 , 6 , 7 , 8 , 9 , 10 , 11 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
DACH1 (human) ( 3 ) , HDAC1 (human) ( 3 ) , HDAC3 (human) ( 3 ) , ING3 (human) ( 1 )
Treatments:
androstanolone ( 3 ) , nicotinamide ( 3 ) , siRNA ( 2 ) , trichostatin_A ( 3 , 6 , 7 , 9 )

Downstream Regulation
Effects of modification on AR:
activity, induced ( 7 , 9 , 10 , 11 ) , intracellular localization ( 1 ) , molecular association, regulation ( 7 , 8 , 10 ) , phosphorylation ( 7 ) , protein stabilization ( 2 )
Effects of modification on biological processes:
apoptosis, induced ( 10 ) , apoptosis, inhibited ( 8 ) , carcinogenesis, induced ( 1 , 8 ) , carcinogenesis, inhibited ( 10 ) , cell growth, induced ( 8 ) , signaling pathway regulation ( 7 ) , transcription, altered ( 4 , 6 ) , transcription, induced ( 5 , 7 , 8 , 9 , 10 , 11 )
Induce interaction with:
DNA ( 7 ) , p300 (human) ( 8 , 10 )
Inhibit interaction with:
HDAC1 (human) ( 8 ) , N-CoR1 (human) ( 8 , 10 ) , SMAD3 (human) ( 8 )

References 

1

Nabbi A, et al. (2017) ING3 promotes prostate cancer growth by activating the androgen receptor. BMC Med 15, 103
28511652   Curated Info

2

Montie HL, Pestell RG, Merry DE (2011) SIRT1 modulates aggregation and toxicity through deacetylation of the androgen receptor in cell models of SBMA. J Neurosci 31, 17425-36
22131404   Curated Info

3

Wu K, et al. (2009) The cell fate determination factor dachshund inhibits androgen receptor signaling and prostate cancer cellular growth. Cancer Res 69, 3347-55
19351840   Curated Info

4

Faus H, Haendler B (2008) Androgen receptor acetylation sites differentially regulate gene control. J Cell Biochem 104, 511-24
18022799   Curated Info

5

Haelens A, et al. (2007) The hinge region regulates DNA binding, nuclear translocation, and transactivation of the androgen receptor. Cancer Res 67, 4514-23
17483368   Curated Info

6

Karvonen U, Jänne OA, Palvimo JJ (2006) Androgen receptor regulates nuclear trafficking and nuclear domain residency of corepressor HDAC7 in a ligand-dependent fashion. Exp Cell Res 312, 3165-83
16860317   Curated Info

7

Fu M, et al. (2004) The androgen receptor acetylation site regulates cAMP and AKT but not ERK-induced activity. J Biol Chem 279, 29436-49
15123687   Curated Info

8

Fu M, et al. (2003) Acetylation of androgen receptor enhances coactivator binding and promotes prostate cancer cell growth. Mol Cell Biol 23, 8563-75
14612401   Curated Info

9

Gaughan L, et al. (2002) Tip60 and histone deacetylase 1 regulate androgen receptor activity through changes to the acetylation status of the receptor. J Biol Chem 277, 25904-13
11994312   Curated Info

10

Fu M, et al. (2002) Androgen receptor acetylation governs trans activation and MEKK1-induced apoptosis without affecting in vitro sumoylation and trans-repression function. Mol Cell Biol 22, 3373-88
11971970   Curated Info

11

Fu M, et al. (2000) p300 and p300/cAMP-response element-binding protein-associated factor acetylate the androgen receptor at sites governing hormone-dependent transactivation. J Biol Chem 275, 20853-60
10779504   Curated Info