Ser354
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Home > Phosphorylation Site Page: > Ser354  -  Nur77 (mouse)

Site Information
GRRGRLPsKPKQPPD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447942

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 2 ) , electrophoretic mobility shift ( 2 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 ) , phosphopeptide mapping ( 2 ) , western blotting ( 1 )
Disease tissue studied:
adrenal cancer ( 1 ) , pheochromocytoma ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Kinases, in vitro:
MSK1 (human) ( 1 ) , p90RSK (human) ( 1 ) , RSK2 (human) ( 1 )
Treatments:
ACTH ( 2 ) , anisomycin ( 1 ) , cAMP_analog ( 2 ) , EGF ( 1 ) , H-89 ( 1 ) , IGF-1 ( 1 ) , NGF ( 1 ) , okadaic_acid ( 2 ) , PD184352 ( 1 ) , phorbol_ester ( 1 ) , Ro31-8220 ( 1 ) , SB203580 ( 1 ) , U0126 ( 1 ) , wortmannin ( 1 )

Downstream Regulation
Effects of modification on Nur77:
activity, inhibited ( 1 , 2 )
Effects of modification on biological processes:
transcription, altered ( 2 )

References 

1

Wingate AD, Campbell DG, Peggie M, Arthur JS (2006) Nur77 is phosphorylated in cells by RSK in response to mitogenic stimulation. Biochem J 393, 715-24
16223362   Curated Info

2

Li Y, Lau LF (1997) Adrenocorticotropic hormone regulates the activities of the orphan nuclear receptor Nur77 through modulation of phosphorylation. Endocrinology 138, 4138-46
9322922   Curated Info