Ser354
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Home > Phosphorylation Site Page: > Ser354  -  Nur77 (mouse)

Site Information
GRRGRLPsKPKQPPD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447942

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 4 ) , electrophoretic mobility shift ( 4 ) , mutation of modification site ( 3 , 4 ) , phospho-antibody ( 1 , 2 , 3 ) , phosphopeptide mapping ( 4 ) , western blotting ( 1 , 2 , 3 )
Disease tissue studied:
adrenal cancer ( 3 ) , pheochromocytoma ( 3 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 3 ) , ES (stem) ( 3 ) , lung ( 2 ) , pancreatic islet ( 1 ) , PC-12 (chromaffin) ( 3 ) , RAW 264.7 (macrophage) ( 2 ) , Y-1 (adrenal cortical) ( 4 )

Upstream Regulation
Regulatory protein:
JNK1 (human) ( 2 )
Kinases, in vitro:
MSK1 (human) ( 3 ) , p90RSK (human) ( 3 ) , RSK2 (human) ( 3 )
Treatments:
ACTH ( 4 ) , anisomycin ( 2 , 3 ) , cAMP_analog ( 4 ) , EGF ( 3 ) , emodin ( 2 ) , H-89 ( 3 ) , IGF-1 ( 3 ) , LPS ( 2 ) , NGF ( 3 ) , okadaic_acid ( 4 ) , PD184352 ( 3 ) , phorbol_ester ( 3 ) , Ro31-8220 ( 3 ) , SB203580 ( 3 ) , SP600125 ( 2 ) , U0126 ( 3 ) , wortmannin ( 3 )

Downstream Regulation
Effects of modification on Nur77:
activity, inhibited ( 3 , 4 )
Effects of modification on biological processes:
transcription, altered ( 4 )

References 

1

Celen C, et al. (2022) Arid1a loss potentiates pancreatic β-cell regeneration through activation of EGF signaling. Cell Rep 41, 111581
36323264   Curated Info

2

Xie P, et al. (2022) Emodin Protects Against Lipopolysaccharide-Induced Acute Lung Injury the JNK/Nur77/c-Jun Signaling Pathway. Front Pharmacol 13, 717271
35370650   Curated Info

3

Wingate AD, Campbell DG, Peggie M, Arthur JS (2006) Nur77 is phosphorylated in cells by RSK in response to mitogenic stimulation. Biochem J 393, 715-24
16223362   Curated Info

4

Li Y, Lau LF (1997) Adrenocorticotropic hormone regulates the activities of the orphan nuclear receptor Nur77 through modulation of phosphorylation. Endocrinology 138, 4138-46
9322922   Curated Info

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