Ser347
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.5.8
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser347  -  MLKL (mouse)

Site Information
SKTQNsIsRtAKSTK   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 29611200

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry (in vitro) ( 2 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
colorectal cancer ( 1 ) , colorectal carcinoma ( 1 ) , fibrosarcoma of soft tissue ( 1 )
Relevant cell line - cell type - tissue:
3T3 (fibroblast) ( 1 ) , fibroblast-embryo ( 1 ) , HeLa (cervical) ( 1 ) , HT-29 (intestinal) ( 1 ) , L929 (fibroblast) ( 1 ) , SVEC (endothelial) ( 1 )

Upstream Regulation
Putative in vivo kinases:
RIPK3 (human) ( 1 )
Kinases, in vitro:
RIPK3 (mouse) ( 2 )

Downstream Regulation
Effects of modification on MLKL:
protein conformation ( 1 )

References 

1

Rodriguez DA, et al. (2016) Characterization of RIPK3-mediated phosphorylation of the activation loop of MLKL during necroptosis. Cell Death Differ 23, 76-88
26024392   Curated Info

2

Murphy JM, et al. (2013) The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism. Immunity 39, 443-53
24012422   Curated Info

Developed with grants from  NIH Logo and literature mining with Linguamatics  I2E Logo Creative Commons License PhosphoSite, created by Cell Signaling Technology is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License.

©2003-2019 Cell Signaling Technology, Inc.