Tyr6

Site Information
__MAKGFyISKSLGI SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 29570700

In vivo Characterization
Methods used to characterize site in vivo:	flow cytometry ( 1 ) , immunoassay ( 1 ) , immunoprecipitation ( 1 ) , mutation of modification site ( 1 , 2 ) , western blotting ( 1 , 2 )
Disease tissue studied:	cervical cancer ( 1 ) , lymphoma ( 2 )
Relevant cell line - cell type - tissue:	C33-A (cervical) ( 1 ) , MEF (fibroblast) ( 1 ) , U-937 (myeloid) ( 2 )

Downstream Regulation
Effects of modification on CD13:	activity, induced ( 1 ) , enzymatic activity, induced ( 1 ) , intracellular localization ( 1 ) , molecular association, regulation ( 1 , 2 ) , receptor recycling, induced ( 1 )
Effects of modification on biological processes:	cell adhesion, induced ( 1 , 2 ) , cell motility, induced ( 1 , 2 ) , cytoskeletal reorganization ( 2 )
Induce interaction with:	ACTN1 (human) ( 2 ) , ARF6 (human) ( 1 ) , IQGAP1 (human) ( 1 )

References
1	Ghosh M, et al. (2019) CD13 tethers the IQGAP1-ARF6-EFA6 complex to the plasma membrane to promote ARF6 activation, β1 integrin recycling, and cell migration. Sci Signal 12 31040262 Curated Info
2	Subramani J, et al. (2013) Tyrosine phosphorylation of CD13 regulates inflammatory cell-cell adhesion and monocyte trafficking. J Immunol 191, 3905-12 23997214 Curated Info