Tyr861

Site Information
ICFENLtyNQAASDS SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 458403
Associated spectra: 1 CST

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 3 , 4 , 5 , 6 ) , mutation of modification site ( 7 , 8 , 9 )
Disease tissue studied:	esophageal cancer ( 3 ) , esophageal carcinoma ( 3 ) , gastric cancer ( 4 ) , liver cancer ( 7 , 9 ) , lung cancer ( 1 , 5 ) , non-small cell lung cancer ( 1 , 5 ) , non-small cell lung adenocarcinoma ( 1 ) , lymphoma ( 6 ) , Hodgkin's lymphoma ( 6 ) , ovarian cancer ( 2 ) , ovarian epithelial carcinoma ( 2 )
Relevant cell line - cell type - tissue:	BaF3 ('B lymphocyte, precursor') ( 8 ) , COS (fibroblast) ( 9 ) , HD-MyZ (myeloid) ( 6 ) , HEK293T (epithelial) ( 8 ) , HepG2 (hepatic) ( 7 , 9 ) , Kyse70 (esophageal) ( 3 ) , LCLC-103H (pulmonary) ( 5 ) , lung ( 1 ) , OVMANA (ovarian) ( 2 ) , SNU-5 (gastric) ( 4 )

Downstream Regulation
Effects of modification on OSMR:	molecular association, regulation ( 9 ) , phosphorylation ( 9 )
Effects of modification on biological processes:	cell growth, altered ( 8 ) , transcription, altered ( 9 )
Induce interaction with:	SHC1 (human) ( 9 )

References
1	Ren H (2011) CST Curation Set: 11784; Year: 2011; Biosample/Treatment: cell line, RP101/untreated; Disease: non-small cell lung adenocarcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
2	Ren H (2011) CST Curation Set: 11303; Year: 2011; Biosample/Treatment: cell line, OVMANA/serum starved; Disease: ovarian epithelial carcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
3	Tucker M (2010) CST Curation Set: 9224; Year: 2010; Biosample/Treatment: cell line, Kyse70/untreated; Disease: esophageal carcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
4	Guo A (2006) CST Curation Set: 1929; Year: 2006; Biosample/Treatment: cell line, SNU-5/-; Disease: gastric carcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
5	Rikova K (2006) CST Curation Set: 1703; Year: 2006; Biosample/Treatment: cell line, LCLC-103H/serum starved; Disease: non-small cell lung cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
6	Gu T (2006) CST Curation Set: 1625; Year: 2006; Biosample/Treatment: cell line, HD-MyZ/untreated; Disease: Hodgkin's lymphoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
7	Stross C, et al. (2006) Oncostatin M receptor-mediated signal transduction is negatively regulated by SOCS3 through a receptor tyrosine-independent mechanism. J Biol Chem 281, 8458-68 16459330 Curated Info
8	Böing I, et al. (2006) Oncostatin M-induced activation of stress-activated MAP kinases depends on tyrosine 861 in the OSM receptor and requires Jak1 but not Src kinases. Cell Signal 18, 50-61 15935618 Curated Info
9	Hermanns HM, et al. (2000) Non-redundant signal transduction of interleukin-6-type cytokines. The adapter protein Shc is specifically recruited to rhe oncostatin M receptor. J Biol Chem 275, 40742-8 11016927 Curated Info