Lys7
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Home > Sumoylation Site Page: > Lys7  -  PR (human)

Site Information
_MTELKAkGPRAPHV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 2890600

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
breast cancer ( 1 )
Relevant cell line - cell type - tissue:
COS7 (fibroblast) ( 1 ) , HEK293T (epithelial) ( 1 ) , HeLa (cervical) ( 1 ) , T47D (breast cell) ( 1 )

Upstream Regulation
Regulatory protein:
PIAS4 (human) ( 1 )
Treatments:
progesterone ( 1 ) , siRNA ( 1 )

Downstream Regulation
Effects of modification on PR:
intracellular localization ( 1 ) , protein conformation ( 1 ) , protein stabilization ( 1 ) , sumoylation ( 1 )
Effects of modification on biological processes:
transcription, inhibited ( 1 )

References 

1

Man JH, et al. (2006) PIAS3 induction of PRB sumoylation represses PRB transactivation by destabilizing its retention in the nucleus. Nucleic Acids Res 34, 5552-66
17020914   Curated Info

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