Lys22
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Home > Sumoylation Site Page: > Lys22  -  ERK5 (mouse)

Site Information
GEPPGRVkAEPVHTA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 2887212

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 2 ) , mutation of modification site ( 1 , 2 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:
CHO (fibroblast) ( 2 ) , HUVEC (endothelial) ( 1 ) , myocyte-heart ( 2 )

Upstream Regulation
Regulatory protein:
MEK5 (human) ( 2 )
Treatments:
H2O2 ( 2 ) , high_glucose ( 2 ) , insulin ( 2 ) , myocardial infarction ( 2 ) , siRNA ( 2 )

Downstream Regulation
Effects of modification on biological processes:
apoptosis, induced ( 2 ) , transcription, inhibited ( 2 )

Disease / Diagnostics Relevance
Relevant diseases:
diabetes mellitus ( 2 )

References 

1

Nigro P, et al. (2010) PKCzeta decreases eNOS protein stability via inhibitory phosphorylation of ERK5. Blood 116, 1971-9
20538799   Curated Info

2

Shishido T, et al. (2008) Effects of MEK5/ERK5 association on small ubiquitin-related modification of ERK5: implications for diabetic ventricular dysfunction after myocardial infarction. Circ Res 102, 1416-25
18467627   Curated Info

3

Woo CH, et al. (2008) Extracellular signal-regulated kinase 5 SUMOylation antagonizes shear stress-induced antiinflammatory response and endothelial nitric oxide synthase expression in endothelial cells. Circ Res 102, 538-45
18218985   Curated Info