Thr579
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.8.2
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Thr579  -  Fe65 (human)

Site Information
SSSREQWtPSHVSVA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 288031700

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , CHO (fibroblast) ( 1 )

Upstream Regulation
Putative in vivo kinases:
GSK3B (human) ( 1 )
Kinases, in vitro:
GSK3B (human) ( 1 )

Downstream Regulation
Effects of modification on Fe65:
intracellular localization ( 1 ) , molecular association, regulation ( 1 ) , protein conformation ( 1 )
Induce interaction with:
APP (human) ( 1 )

References 

1

Lee YS, Chow WNV, Lau KF (2017) Phosphorylation of FE65 at threonine 579 by GSK3β stimulates amyloid precursor protein processing. Sci Rep 7, 12456
28963516   Curated Info

PhosphoSitePlus® is a registered trademark of Cell Signaling Technology.
Use of PSP data is subject to a formal license agreement. Learn more

©2003-2025 Cell Signaling Technology, Inc.